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IGCSE · Cambridge (CIE) · 0610

Explain coronary artery blockage and muscle supply

Link a narrowed coronary lumen to reduced oxygen delivery to the heart wall.

Section 9.2 · Heart

Heart pathway · 9.2

Core and Extended; Biology 0610, 2026–2028. Use the stated specimen features and evidence. Diagrams are schematic. Written practice is self-checked

Before you begin

  • Recall coronary arteries and cellular respiration.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

What is a coronary artery lumen?

What you will learn

  • Plaque narrows the supply route
  • Follow supply, respiration and contraction
Simplified coronary artery sections: wall deposits narrow the lumen, which can reduce blood delivery to heart muscle. No clinical flow or diagnosis is measured.Supply vessel narrowingOpen lumenBlood routeNarrowed lumenDeposit reduces open space
Simplified coronary artery sections: wall deposits narrow the lumen, which can reduce blood delivery to heart muscle. No clinical flow or diagnosis is measured.

Plaque narrows the supply route

Coronary heart disease can involve fatty deposits building up in coronary artery walls, narrowing their lumen and reducing blood flow to heart muscle. A clot can cause a further blockage. The lumen is the space through which blood flows; the deposit is in the artery wall, not a lump of food inside a heart chamber.

Less flow can reduce oxygen and nutrient delivery to the muscle. The cells need oxygen for aerobic respiration, which provides energy for contraction. A severe interruption can damage heart muscle. Do not confuse coronary artery narrowing with a blocked airway or a faulty one-way valve.

Follow supply, respiration and contraction

A linked explanation is artery narrowing → reduced muscle blood supply → reduced oxygen for aerobic respiration → less energy available for contraction. That chain explains why a problem in a supply vessel can affect pumping, even when blood is still present inside the chambers.

The diagram contrasts an open lumen with a narrowed one as a simplified teaching model. It gives no clinical percentage stenosis, flow measurement or diagnosis. You cannot infer a person’s coronary condition from a school pulse count or from the normal pig-heart surface image.

Pause and explain

Which chain explains the effect of narrowing?

Put the idea to work

Worked example

Explain why reduced coronary blood flow can affect pumping.

Show the worked solution
  1. Less blood reaches muscle, reducing oxygen delivery.
  2. Less aerobic respiration can mean less energy for contraction.

Answer Reduced coronary supply can limit oxygen for muscle respiration and energy for contraction.

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Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

State what narrows and what tissue loses supply in coronary heart disease.

Give me a hint

Name the artery lumen and its destination.

Compare my reasoning
  1. Deposits narrow the coronary artery lumen.
  2. Heart muscle receives less blood.

Coronary artery lumen narrows; blood supply to heart muscle is reduced.

Look for these in your work

  • Correct vessel structure
  • Correct tissue destination
2 · Independent

Explain why chamber blood does not remove the need for an unobstructed coronary supply.

Give me a hint

Heart muscle cells need delivery through their supply vessels.

Compare my reasoning
  1. The chambers carry blood for the main circulation.
  2. Coronary vessels deliver oxygen and nutrients to the muscle itself.

Chamber contents do not replace coronary delivery to muscle cells, which need oxygen and nutrients for respiration and contraction.

Look for these in your work

  • Distinguish chamber and tissue supply
  • Link supply with muscle respiration
3 · Transfer

A learner infers coronary blockage from one elevated pulse count after exercise. Why is this not justified?

Give me a hint

A rate response is not an image or measurement of a coronary lumen.

Compare my reasoning
  1. Activity itself can raise heart rate.
  2. The observation does not establish narrowing or diagnose disease.

The count shows a rate response, not coronary lumen blockage; the claim needs appropriate clinical evidence beyond this exercise.

Look for these in your work

  • Identify the alternative activity explanation
  • Respect the evidence limit

Common mistakes

  • Calling the coronary blockage a valve.
  • Saying oxygen supplies energy without mentioning respiration.
Recall without your notes

What can you explain now?

Which chain explains the effect of narrowing?

Compare with the explanation

Less flow → less oxygen for muscle respiration → less energy for contraction

It links vessel supply to muscle function.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Explain the complete chain from a narrowed lumen to a possible pumping effect.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Biology

Course scope and assessment

780 sequenced lessons provide 2340 guided, independent and application problems in characteristics, classification, cells, organisation, specimen size, membrane transport, biological molecules, enzymes, plant and human nutrition, plant transport, circulatory systems, the heart, blood vessels, blood, disease transmission, body defences, immunity, gas exchange in humans, respiration energy uses and investigations, aerobic respiration, anaerobic respiration and recovery, excretion in humans, coordination and response, sense organs, hormones, homeostasis, tropic responses, drugs, asexual reproduction, sexual reproduction, sexual reproduction in plants, sexual reproduction in humans, sex hormones in humans, sexually transmitted infections, chromosomes, genes and proteins, mitosis, meiosis, monohybrid inheritance, variation, adaptive features, selection, energy flow, food chains and webs, nutrient cycles, population, community, ecosystem, population-growth phases, food supply, habitat destruction, pollution, conservation, biotechnology and genetic modification. 61 of 61 syllabus sections have linked teaching and staged practice. The earlier inheritance overview remains introductory, and the monohybrid pathway develops the relevant Core and Supplement requirements. This is not full programme completion or guaranteed exam readiness. Written practice is self-checked.

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