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IGCSE · Cambridge (CIE) · 0653

Locate oestrogen production through the ovarian cycle

Oestrogen sources in the cycle: developing ovarian follicles and, after ovulation, the corpus luteum. The uterine lining is a target for rebuilding, not the ovarian source.

Section B14.2 · Sexual reproduction in humans

Sexual reproduction in humans · Cambridge IGCSE Combined Science 0653 · B14.2

Cross-referenced to the 2028–2029 0653 section using original teaching from the related single-science courses. A 0653-specific objective-by-objective and Core/Supplement review is in progress. Written practice is self-checked and does not demonstrate supervised laboratory competence or award an official Cambridge grade.

Before you begin

  • Recall endocrine glands, blood-borne hormones, ovaries, testes, uterine lining, ovulation and implantation.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

Which is an oestrogen source before ovulation?

What you will learn

  • Name ovarian structures producing oestrogen
  • Separate a hormone source from its target

Original teaching model.

Locate oestrogen production through the ovarian cycleOestrogen sources in the cycle: developing ovarian follicles and, after ovulation, the corpus luteum. The uterine lining is a target for rebuilding, not the ovarian source.Before ovulationDeveloping ovarian follicleAfter ovulationCorpus luteum also contributesOestrogen travels in bloodUterine lining is a targetPregnancy sources changePlacenta important later
Oestrogen sources in the cycle: developing ovarian follicles and, after ovulation, the corpus luteum. The uterine lining is a target for rebuilding, not the ovarian source.
Event and hormone key
FeatureMeaning
Before ovulationDeveloping ovarian follicle
After ovulationCorpus luteum also secretes oestrogen
TransportBlood
Target responseUterine-lining rebuilding

Name ovarian structures producing oestrogen

During the menstrual cycle, oestrogen is produced in the ovaries. A developing follicle is an important source before ovulation. Follicular cells secrete hormone into blood as the follicle develops. The egg enclosed by the follicle is not itself a bottle of hormone sent down an oviduct: distinguish the endocrine tissue from the gamete it surrounds.

After ovulation the remaining follicular tissue forms the corpus luteum, which produces progesterone and also oestrogen. It would therefore be misleading to claim that oestrogen production can only occur before egg release. A typical cycle includes a rise before ovulation and a smaller rise later; the precise values in any classroom graph are model values rather than a reference range.

Separate a hormone source from its target

The uterine lining is a responding target for oestrogen, not the ovarian source in this explanation. Oestrogen supports rebuilding and thickening of the lining. Blood transport connects a source in the ovary with a target in the uterus. A complete source question requires an organ or tissue; a complete function question requires the response as well.

The original source map contrasts developing follicle and corpus luteum, then connects both to blood-borne secretion. Pregnancy introduces an additional placental source later, which is treated separately. Do not assume that the tissue receiving hormone must be the tissue that secreted it, or that a graph showing a rise directly photographs the source.

Sources for this lesson

Pause and explain

Which source can also produce oestrogen after ovulation?

Put the idea to work

Worked example

Name an oestrogen source before and after ovulation.

Show the worked solution
  1. Identify developing ovarian follicle before release.
  2. Identify corpus luteum after release.

Answer Developing ovarian follicles produce oestrogen before ovulation; the ovarian corpus luteum also produces oestrogen after ovulation.

Try a topic test

Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

Test this topic →

From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

State the organ and structure producing much of the pre-ovulation oestrogen.

Give me a hint

Give a broad organ and a more precise tissue.

Compare my reasoning
  1. Name ovary.
  2. Name developing follicle.

The ovary, especially the developing follicle, produces oestrogen before ovulation.

Look for these in your work

  • Name organ
  • Name follicle
2 · Independent

Explain why “only the egg secretes all oestrogen” is an inaccurate source statement.

Give me a hint

Separate enclosed gamete from endocrine tissues.

Compare my reasoning
  1. Name developing follicular tissue.
  2. Include corpus luteum after ovulation.

Oestrogen is secreted by ovarian tissues including developing follicles and later the corpus luteum; the egg is not the sole endocrine source.

Look for these in your work

  • Correct the tissue category
  • Include both stages
3 · Transfer

A diagram labels uterine lining as source and follicle as target. Repair the pre-ovulation pathway.

Give me a hint

Trace secretion, blood transport and response.

Compare my reasoning
  1. Place secretion in ovarian follicle.
  2. Place rebuilding response at uterine lining.

Ovarian follicle → oestrogen in blood → uterine-lining rebuilding and thickening.

Look for these in your work

  • Correct direction
  • Separate source and response

Common mistakes

  • A target is not necessarily a source.
  • Oestrogen production does not stop simply because ovulation occurred.
Recall without your notes

What can you explain now?

Which source can also produce oestrogen after ovulation?

Compare with the explanation

Corpus luteum in the ovary

It also secretes progesterone.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Explain name ovarian structures producing oestrogen and separate a hormone source from its target. Follow the event arrows or graph labels before opening the solutions.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Science — Combined

Course scope and assessment

This pathway maps all 121 detailed subject-content sections in the published 0653 syllabus for exams in 2028 and 2029. It adapts original lessons from the related single-science pathways and keeps Combined Science's narrower scope: Biology B1–B16, Chemistry C1–C12 and Physics P1–P5. A 0653-specific objective-by-objective review, Core/Supplement audit, human subject-teacher review, supervised laboratory experience and cumulative assessment remain in progress. Written practice is self-checked and does not predict an official grade. The separate 2025–2027 syllabus has not been reconciled here; choose the 2028–2029 syllabus only.

StudyForA · Learn with understanding

Original teaching content and links to official sources. Check your exam year and qualification before using a resource.