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IGCSE · Cambridge (CIE) · 0654

Describe changing oestrogen and progesterone sources in pregnancy

Pregnancy source map: ovarian corpus luteum contributes early; the placenta later becomes a major source of oestrogen and progesterone. The transition is gradual, not instant at fertilisation.

Section B15.4 · Sexual reproduction in humans

Sexual reproduction in humans · Cambridge IGCSE 0654 · B15.4

Mapped to the named 0654 section using teaching from the corresponding single-science course. A 0654-specific review of every Core and Supplement objective is still in progress. Written practice is self-checked; it does not demonstrate supervised laboratory competence or award an official Cambridge grade.

Before you begin

  • Recall endocrine glands, blood-borne hormones, ovaries, testes, uterine lining, ovulation and implantation.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

Which pairing correctly gives early and later sources?

What you will learn

  • Separate early ovarian support from later placental production
  • Avoid an instant source-switch explanation

Original teaching model.

Describe changing oestrogen and progesterone sources in pregnancyPregnancy source map: ovarian corpus luteum contributes early; the placenta later becomes a major source of oestrogen and progesterone. The transition is gradual, not instant at fertilisation.Early pregnancyCorpus luteum in ovaryGradual transitionPlacenta developsLater pregnancyPlacenta: major hormone sourceContinued supportOestrogen and progesterone
Pregnancy source map: ovarian corpus luteum contributes early; the placenta later becomes a major source of oestrogen and progesterone. The transition is gradual, not instant at fertilisation.
Event and hormone key
FeatureMeaning
Early pregnancyOvarian corpus luteum
Later pregnancyPlacenta becomes a major source
HormonesOestrogen and progesterone
Model limitNo universal switch day or clinical value

Separate early ovarian support from later placental production

The sites of oestrogen and progesterone production change in their relative importance during pregnancy. The ovarian corpus luteum is important in early pregnancy and continues to support hormone production. The developing placenta later becomes a major source of these hormones. An answer should name both the early ovarian structure and the later placental source instead of choosing only one for the entire pregnancy.

The transition is gradual rather than an instantaneous switch at fertilisation. A newly formed zygote does not already have a mature placenta, and early implantation does not mean the ovarian corpus luteum has immediately stopped functioning. The source diagram therefore separates early and later stages without imposing one exact day as a universal boundary.

Avoid an instant source-switch explanation

Oestrogen and progesterone produced during pregnancy contribute to continued uterine support. Progesterone helps maintain the lining instead of the ordinary cyclic withdrawal followed by menstruation. The placenta has both an exchange role and an endocrine role. Maternal and fetal blood systems normally remaining separate does not prevent a placental tissue from producing hormones.

The syllabus focus is the production sites and the four named hormones in cycle and pregnancy control. Other pregnancy signals and detailed biochemical pathways are outside the explanation required here. The source map gives a stage relationship, not a blood-test interpretation, individual viability prediction or hormone treatment schedule.

Sources for this lesson

Pause and explain

How should the source transition be described?

Put the idea to work

Worked example

Name the important progesterone sources early and later in pregnancy.

Show the worked solution
  1. Name early corpus luteum in ovary.
  2. Name later major placental source.

Answer Early pregnancy: ovarian corpus luteum. Later pregnancy: placenta becomes the major source. The transition is gradual.

Try a topic test

Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

Give early and later pregnancy sources for oestrogen and progesterone at this syllabus level.

Give me a hint

Use ovarian corpus luteum and placenta.

Compare my reasoning
  1. Identify early corpus-luteum contribution.
  2. Identify later major placental contribution.

The ovarian corpus luteum contributes early; the placenta later becomes a major source of oestrogen and progesterone.

Look for these in your work

  • Name both sources
  • State the stage relationship
2 · Independent

Explain why “fertilisation immediately replaces the corpus luteum with a mature placenta” is inaccurate.

Give me a hint

Separate nuclear fusion from later placental development.

Compare my reasoning
  1. Recognise a zygote forms at fertilisation.
  2. Retain early corpus-luteum support and gradual placental development.

Fertilisation forms a zygote, not a mature placenta. The corpus luteum supports early hormone production; placental production becomes important as the placenta develops.

Look for these in your work

  • Correct the developmental timing
  • Include early support
3 · Transfer

A source map shows corpus luteum early and placenta later but supplies no blood-test data. What can and cannot be concluded?

Give me a hint

Use source stages without a clinical inference.

Compare my reasoning
  1. State the changing sources.
  2. Reject a personal concentration or viability claim.

The map supports the early ovarian and later placental source relationship; it does not measure an individual hormone concentration or establish a pregnancy outcome.

Look for these in your work

  • Give the supported relationship
  • Name the evidence limit

Common mistakes

  • A zygote is not a mature placenta.
  • Later placental production does not erase early ovarian support.
Recall without your notes

What can you explain now?

How should the source transition be described?

Compare with the explanation

Gradual, with changing relative importance

It is not an instant universal-day switch.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Explain separate early ovarian support from later placental production and avoid an instant source-switch explanation. Follow the event arrows or graph labels before opening the solutions.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Sciences — Co-ordinated (Double)

Course scope and assessment

This 2028–2029 pathway maps all 152 detailed subject-content sections in the published 0654 syllabus to original teaching and staged practice. It adapts teaching from the related single-science pathways and excludes clear 0610-only topics such as classification systems, human excretion, tropic responses, food supply, population dynamics, detailed pollution and biotechnology. Some explanations may include wider single-science context. A 0654-specific objective-by-objective review, Core/Supplement audit, human subject-teacher review, supervised laboratory experience and cumulative assessment remain in progress. Written practice is self-checked and does not predict an official grade. The 2025–2027 syllabus has not been reconciled here; choose the 2028–2029 syllabus only.

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