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IGCSE · Cambridge (CIE) · 0610

Balance the aerobic respiration chemical equation

Preserve molecule formulae and count all three elements.

Section 12.2 · Aerobic respiration

Aerobic respiration pathway · 12.2

Extended only (Supplement); Biology 0610, 2026–2028. Use the stated specimen features and evidence. Diagrams are schematic. Written practice is self-checked

Before you begin

  • Recall cell processes, enzymes and the distinction between gas exchange and breathing.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

How many oxygen atoms are in 3O₂?

What you will learn

  • Balance coefficients not subscripts
  • Check carbon hydrogen and oxygen

Balance the aerobic respiration chemical equation

Respiration model reference
FeatureMeaning
GlucoseC₆H₁₂O₆
Oxygen6O₂
Carbon dioxide6CO₂
Water6H₂O
Oxygen atom check18 on each side
Original teaching model. Atom counts are conserved with coefficients 1 : 6 : 6 : 6. The total number of molecules need not stay equal.

Balance coefficients not subscripts

The balanced aerobic equation is C₆H₁₂O₆ + 6O₂ → 6CO₂ + 6H₂O. Each formula names a substance. Coefficients multiply whole formula units; changing a subscript changes the substance. Glucose contains six carbon, twelve hydrogen and six oxygen atoms in each molecule, while an oxygen molecule contains two oxygen atoms.

Start from one glucose. Six carbon atoms require six carbon-dioxide molecules. Twelve hydrogen atoms require six water molecules. The products then contain twelve oxygen atoms in carbon dioxide and six in water, making eighteen. The glucose supplies six; the other twelve come from six oxygen molecules.

Check carbon hydrogen and oxygen

Check each element on both sides: carbon six and six, hydrogen twelve and twelve, oxygen eighteen and eighteen. A balanced equation conserves atom counts, not the count of molecules. It does not assert that all the enzyme-catalysed reactions occur in one collision or that a single event can be seen in an anatomical diagram.

This symbolic equation is a Supplement requirement for Extended learners. Write the correct formulae before balancing and retain the whole-number coefficients. Energy release belongs to the process explanation and does not add chemical atoms. Coefficients show relative amounts under the specified overall reaction, not a respiratory rate unless a time is supplied.

Pause and explain

Which coefficient multiplies water in the balanced one-glucose equation?

Put the idea to work

Worked example

Why is the oxygen coefficient six?

Show the worked solution
  1. Products contain 18 oxygen atoms; glucose supplies 6.
  2. The remaining 12 require 6 molecules of O₂.

Answer Six O₂ molecules supply the remaining twelve oxygen atoms.

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Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

State the balanced aerobic equation for one glucose molecule.

Give me a hint

Balance carbon and hydrogen before the remaining oxygen.

Compare my reasoning
  1. Use 6CO₂ and 6H₂O for carbon and hydrogen.
  2. Add 6O₂ to supply the remaining oxygen.

C₆H₁₂O₆ + 6O₂ → 6CO₂ + 6H₂O.

Look for these in your work

  • Retain formulae
  • Give all three coefficients
2 · Independent

Count the oxygen atoms on each side of that balanced equation.

Give me a hint

Include oxygen already in glucose.

Compare my reasoning
  1. Left: 6 + 6 × 2 = 18.
  2. Right: 6 × 2 + 6 × 1 = 18.

Eighteen oxygen atoms on each side.

Look for these in your work

  • Include glucose oxygen
  • Check both products
3 · Transfer

A student changes water to H₁₂O to fix hydrogen. Explain the error and repair it.

Give me a hint

A coefficient preserves the water formula.

Compare my reasoning
  1. H₂O is the formula of water.
  2. Six H₂O supplies twelve hydrogen atoms.

Keep H₂O and use coefficient 6; changing its subscripts changes the substance rather than balancing water.

Look for these in your work

  • Preserve the formula
  • Use a coefficient

Common mistakes

  • Changing O₂ to O₆ to balance.
  • Balancing only carbon while ignoring oxygen.
Recall without your notes

What can you explain now?

Which coefficient multiplies water in the balanced one-glucose equation?

Compare with the explanation

Six

Six H₂O gives twelve hydrogen atoms.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Balance the equation by coefficients and check all three elements.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Biology

Course scope and assessment

780 sequenced lessons provide 2340 guided, independent and application problems in characteristics, classification, cells, organisation, specimen size, membrane transport, biological molecules, enzymes, plant and human nutrition, plant transport, circulatory systems, the heart, blood vessels, blood, disease transmission, body defences, immunity, gas exchange in humans, respiration energy uses and investigations, aerobic respiration, anaerobic respiration and recovery, excretion in humans, coordination and response, sense organs, hormones, homeostasis, tropic responses, drugs, asexual reproduction, sexual reproduction, sexual reproduction in plants, sexual reproduction in humans, sex hormones in humans, sexually transmitted infections, chromosomes, genes and proteins, mitosis, meiosis, monohybrid inheritance, variation, adaptive features, selection, energy flow, food chains and webs, nutrient cycles, population, community, ecosystem, population-growth phases, food supply, habitat destruction, pollution, conservation, biotechnology and genetic modification. 61 of 61 syllabus sections have linked teaching and staged practice. The earlier inheritance overview remains introductory, and the monohybrid pathway develops the relevant Core and Supplement requirements. This is not full programme completion or guaranteed exam readiness. Written practice is self-checked.

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