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IGCSE · Cambridge (CIE) · 0610

Describe stem cells and the potential of their daughter cells

An unspecialised stem cell divides by mitosis. Its daughters can later specialise for specific functions; the diagram shows one possible outcome rather than every stem-cell population.

Section 17.2 · Mitosis

Mitosis pathway · 17.2

Extended only (Supplement); Biology 0610, 2026–2028. Use the stated specimen features and evidence. Diagrams are schematic. Written practice is self-checked

Before you begin

  • Recall chromosomes, genes, chromosome sets, selective gene expression and the distinction between a nucleus and a whole cell.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

Which statement fits the syllabus definition of a stem cell?

What you will learn

  • Define an unspecialised stem cell
  • Connect division with later specialisation

Original teaching model. Counts and records are stipulated; drawings are schematic.

Describe stem cells and the potential of their daughter cellsAn unspecialised stem cell divides by mitosis. Its daughters can later specialise for specific functions; the diagram shows one possible outcome rather than every stem-cell population.One possible stem-cell lineageStem cellUnspecialisedNormal mitosisLater daughter statesStem daughterRetains stemstateDescendantLater specialisesShared genetic information;different later useSpecific potential depends on the stated populationDrawing colours label states, not DNA sequences
An unspecialised stem cell divides by mitosis. Its daughters can later specialise for specific functions; the diagram shows one possible outcome rather than every stem-cell population.
Division, chromosome count and cell-state key
FeatureMeaning
Starting stateUnspecialised stem cell with genetic information
DivisionMitosis produces daughter cells
PotentialDaughters can specialise for specific functions
LimitNot every stem cell can produce every possible type

Define an unspecialised stem cell

A stem cell is an unspecialised cell that divides by mitosis to produce daughter cells that can become specialised for particular functions. Unspecialised does not mean the cell has no genes or performs no cellular activities. It means that it has not taken on the specific specialised role being considered, such as the mature function of a cell type in a supplied tissue model.

Mitosis and specialisation are different parts of the explanation. Mitosis distributes copied chromosome information to daughter nuclei. A daughter can subsequently develop the structures and protein-expression pattern needed for a particular function. The division does not require one daughter to receive a deliberately incomplete genetic complement in order to become different from the other.

Connect division with later specialisation

Different stem-cell populations have different potential cell types. The syllabus definition does not mean that every stem cell can become every possible type of body cell. When an original question states that a population can make cell types F and G, use those given possibilities rather than adding unsupported types or a guarantee that every daughter must immediately specialise.

The teaching diagram uses labels and colours to show cell states in one possible lineage. A coloured circle is not experimental evidence of a cell's identity or differentiation potential. The explanation follows the supplied stem-cell definition and model observations; practical demonstration of a real cell population's potential and any clinical treatment claim require evidence beyond this written lesson.

Pause and explain

Does the definition prove every stem cell can become every cell type?

Put the idea to work

Worked example

What links an unspecialised stem cell with a specialised daughter?

Show the worked solution
  1. Identify mitotic daughter-cell production.
  2. Identify later development of a specific function.

Answer The stem cell divides by mitosis; a daughter can subsequently specialise for a specific function.

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Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

Give a complete stem-cell description for this syllabus.

Give me a hint

Include state, division and daughter potential.

Compare my reasoning
  1. Identify an unspecialised cell.
  2. Connect mitosis with daughter cells that can specialise.

A stem cell is an unspecialised cell that divides by mitosis to produce daughter cells that can become specialised for specific functions.

Look for these in your work

  • Include all three links
  • Use potential rather than a forced outcome
2 · Independent

A supplied population can produce types F and G. Explain the supported daughter-cell potential.

Give me a hint

Use only the stated types.

Compare my reasoning
  1. Identify F and G as the supported possibilities.
  2. Keep mitosis distinct from later specialisation.

Its mitotic daughters can specialise into the supplied types F and G; the record does not establish every other cell type.

Look for these in your work

  • Use the given population
  • Retain the evidence limit
3 · Transfer

A diagram colours one cell green and calls it a stem cell. Does colour alone establish its biological potential?

Give me a hint

A label is not an experiment.

Compare my reasoning
  1. Identify colour as a schematic key.
  2. State that potential needs supported observations.

No. Colour is a drawing key, not biological evidence of unspecialised status or the ability to produce specialised daughters.

Look for these in your work

  • Distinguish schematic labels and evidence
  • State the missing demonstration

Common mistakes

  • Unspecialised does not mean lacking genetic information.
  • Different stem-cell populations do not all have unlimited potential.
Recall without your notes

What can you explain now?

Does the definition prove every stem cell can become every cell type?

Compare with the explanation

No; potential depends on the stated population

Use the cell types supported by the model or evidence.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Without your notes, define an unspecialised stem cell and connect division with later specialisation. Distinguish nuclear division, chromosome copies and completed daughter cells before opening the solutions.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Biology

Course scope and assessment

780 sequenced lessons provide 2340 guided, independent and application problems in characteristics, classification, cells, organisation, specimen size, membrane transport, biological molecules, enzymes, plant and human nutrition, plant transport, circulatory systems, the heart, blood vessels, blood, disease transmission, body defences, immunity, gas exchange in humans, respiration energy uses and investigations, aerobic respiration, anaerobic respiration and recovery, excretion in humans, coordination and response, sense organs, hormones, homeostasis, tropic responses, drugs, asexual reproduction, sexual reproduction, sexual reproduction in plants, sexual reproduction in humans, sex hormones in humans, sexually transmitted infections, chromosomes, genes and proteins, mitosis, meiosis, monohybrid inheritance, variation, adaptive features, selection, energy flow, food chains and webs, nutrient cycles, population, community, ecosystem, population-growth phases, food supply, habitat destruction, pollution, conservation, biotechnology and genetic modification. 61 of 61 syllabus sections have linked teaching and staged practice. The earlier inheritance overview remains introductory, and the monohybrid pathway develops the relevant Core and Supplement requirements. This is not full programme completion or guaranteed exam readiness. Written practice is self-checked.

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