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IGCSE · Cambridge (CIE) · 0610

Interpret conditional mitotic lineage counts without inventing a growth rate

Invented full-round totals are 3, 6, 12 and 24 cells, requiring 21 completed events. If only three of eight cells divide once, the new total is eleven; the chart is not a time-based growth forecast.

Section 17.2 · Mitosis

Mitosis pathway · 17.2

Extended only (Supplement); Biology 0610, 2026–2028. Use the stated specimen features and evidence. Diagrams are schematic. Written practice is self-checked

Before you begin

  • Recall chromosomes, genes, chromosome sets, selective gene expression and the distinction between a nucleus and a whole cell.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

Three starting cells complete three full no-loss doubling rounds. What is the final count?

What you will learn

  • Count completed events and whole-population rounds
  • Handle a partially dividing population

Original teaching model. Counts and records are stipulated; drawings are schematic.

Interpret conditional mitotic lineage counts without inventing a growth rateInvented full-round totals are 3, 6, 12 and 24 cells, requiring 21 completed events. If only three of eight cells divide once, the new total is eleven; the chart is not a time-based growth forecast.Invented completed-cell lineageEvery cell divides once per round;no loss0816243061122243Model round, not elapsed hours21 events; final 24; net increase 21Partial round: only 3 of 8 divide →11 cells
Invented full-round totals are 3, 6, 12 and 24 cells, requiring 21 completed events. If only three of eight cells divide once, the new total is eleven; the chart is not a time-based growth forecast.
Division, chromosome count and cell-state key
FeatureMeaning
Model rounds0, 1, 2 and 3; not hours
Cell totals3, 6, 12 and 24
Completed events3 + 6 + 12 = 21
Partial round8 cells + 3 net additions = 11

Count completed events and whole-population rounds

A mitotic lineage model counts completed cell divisions, not only nuclear snapshots. One parent replaced by two daughter cells adds one cell. If every cell in a population completes one division in each stated round and no cells are lost or added from elsewhere, the population doubles per round. Those assumptions make a calculation possible; mitosis alone does not supply them.

An original record starts with three cells. Whole-population rounds zero, one, two and three contain three, six, twelve and twenty-four cells. The final twenty-four is eight times the initial three, and the net increase is twenty-one. The individual division-event counts are three, six and twelve in the three rounds, also totalling twenty-one events.

Handle a partially dividing population

A partial round gives a different result. If eight cells are present and only three complete division, the other five remain single cells while the three parents become six daughters. The final population is eleven, not sixteen. Equivalently, add one net cell for each of the three completed events: eight plus three. A round label does not imply that every cell divided.

The chart's horizontal axis counts model rounds, not hours, and its vertical axis counts cells. It therefore gives no measured division speed, time to repair or real tissue growth forecast. Cells in organisms differ in division behaviour, and loss or migration changes population totals. Preserve the supplied assumptions and use comparable per-cell chromosome counts when discussing the genetic outcome.

Pause and explain

Eight cells are present; only three complete division. What is the new count with no other changes?

Put the idea to work

Worked example

Three cells complete three full doubling rounds with no loss. Count the final cells and events.

Show the worked solution
  1. Use three, six, twelve, twenty-four.
  2. Sum three plus six plus twelve events.

Answer There are twenty-four cells after twenty-one completed division events, a net increase of twenty-one.

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Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

Calculate the three-cell lineage after three complete no-loss rounds.

Give me a hint

Double the entire population at each stated round.

Compare my reasoning
  1. Calculate three to six to twelve to twenty-four.
  2. Subtract the initial three from the final total.

The final population is twenty-four cells, with a net increase of twenty-one.

Look for these in your work

  • Use the stated assumptions
  • Separate final total and increase
2 · Independent

Independently calculate the individual completed events across those three rounds.

Give me a hint

Count the parents dividing in each round.

Compare my reasoning
  1. Count three, six and twelve events.
  2. Add the three event counts.

The rounds contain three, six and twelve completed division events, totalling twenty-one events.

Look for these in your work

  • Count events rather than rounds
  • Show the addition
3 · Transfer

Eight cells are present and exactly three divide once; calculate the final population and state why it does not double.

Give me a hint

Five stay single and three become six daughters.

Compare my reasoning
  1. Count five undivided cells plus six daughters.
  2. Compare with whole-population doubling.

The final population is eleven cells. It does not double because only three of the eight original cells divide.

Look for these in your work

  • Include the undivided cells
  • Retain the partial-division condition

Common mistakes

  • A round is not an individual division event.
  • Only the stated cells divide in a partial-round model.
Recall without your notes

What can you explain now?

Eight cells are present; only three complete division. What is the new count with no other changes?

Compare with the explanation

Eleven

Each of the three events adds one net cell.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Without your notes, count completed events and whole-population rounds and handle a partially dividing population. Distinguish nuclear division, chromosome copies and completed daughter cells before opening the solutions.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Biology

Course scope and assessment

780 sequenced lessons provide 2340 guided, independent and application problems in characteristics, classification, cells, organisation, specimen size, membrane transport, biological molecules, enzymes, plant and human nutrition, plant transport, circulatory systems, the heart, blood vessels, blood, disease transmission, body defences, immunity, gas exchange in humans, respiration energy uses and investigations, aerobic respiration, anaerobic respiration and recovery, excretion in humans, coordination and response, sense organs, hormones, homeostasis, tropic responses, drugs, asexual reproduction, sexual reproduction, sexual reproduction in plants, sexual reproduction in humans, sex hormones in humans, sexually transmitted infections, chromosomes, genes and proteins, mitosis, meiosis, monohybrid inheritance, variation, adaptive features, selection, energy flow, food chains and webs, nutrient cycles, population, community, ecosystem, population-growth phases, food supply, habitat destruction, pollution, conservation, biotechnology and genetic modification. 61 of 61 syllabus sections have linked teaching and staged practice. The earlier inheritance overview remains introductory, and the monohybrid pathway develops the relevant Core and Supplement requirements. This is not full programme completion or guaranteed exam readiness. Written practice is self-checked.

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