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IGCSE · Cambridge (CIE) · 0610

Identify red and white blood cells in diagrams

Use nucleus, cell outline and central pallor in a schematic comparison.

Section 9.4 · Blood

Blood pathway · 9.4

Core and Extended; Biology 0610, 2026–2028. Use the stated specimen features and evidence. Diagrams are schematic. Written practice is self-checked

Before you begin

  • Recall the four blood components.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

What is a nucleus?

What you will learn

  • Recognise the mature red-cell pattern
  • White cells retain a nucleus
A mature human red cell; B and C white cells. Central pallor in A is not a nucleus or an open hole. Relative drawn sizes are schematic.Red cells and nucleatedwhite cellsA: mature red cellCentral pallor; no nucleusB: lymphocyteLarge round nucleusC: phagocyte (neutrophil)Lobed nucleus; cytoplasm
A mature human red cell; B and C white cells. Central pallor in A is not a nucleus or an open hole. Relative drawn sizes are schematic. Original schematic, not to scale.

Recognise the mature red-cell pattern

The original diagram labels A as a mature human red blood cell. It is drawn as a biconcave disc viewed from above: the centre is paler than the rim, and there is no nucleus. The pale centre represents the thinner central region, not an open hole through the cell.

Mature human red cells lack a nucleus, but not all animals have that pattern and developing cells differ. Use the stated human specimen. A drawing is simplified and not to scale; its size on the screen does not provide an actual diameter.

White cells retain a nucleus

B and C are white blood cells. B has a large round nucleus; C has a lobed nucleus with surrounding cytoplasm. Their shared nucleated pattern distinguishes them from mature human red cells. White cells have different shapes and functions, so do not insist that every white-cell nucleus looks the same.

Colour is a teaching convention in this diagram. Identify A using its disc-like outline and lack of nucleus, and B/C using their nuclei. The detailed lymphocyte/phagocyte names are explored in the Extended sequence. Core identification here asks for red or white cells using observable features rather than disease diagnosis.

Pause and explain

Which diagram feature supports white-cell identification?

Put the idea to work

Worked example

Identify A and B/C as red or white cells and give evidence independent of colour.

Show the worked solution
  1. A has no nucleus and a paler disc centre.
  2. B and C contain nuclei.

Answer A mature human red cell; B and C white cells. The presence or absence of a nucleus supports the distinction.

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Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

Identify A and state two visible features supporting the answer.

Give me a hint

Use shape and nucleus evidence.

Compare my reasoning
  1. A is disc-like with a paler central region.
  2. It has no nucleus.

A mature human red blood cell: disc-like central pallor and no nucleus.

Look for these in your work

  • Name the cell
  • Use two structural features
2 · Independent

Identify B and C at the Core red/white-cell level.

Give me a hint

Their nucleus shapes differ but both have one.

Compare my reasoning
  1. B has a round nucleus.
  2. C has a lobed nucleus.

B and C are white blood cells; both contain a nucleus.

Look for these in your work

  • Identify both
  • Use nucleus evidence
3 · Transfer

The diagram is printed in grayscale. How can A still be distinguished from B and C?

Give me a hint

Focus on structures rather than colour.

Compare my reasoning
  1. A lacks a nucleus and has a pale disc centre.
  2. B/C show nuclei and surrounding cytoplasm.

Use A’s lack of nucleus and disc structure versus the nuclei in B/C; colour is unnecessary.

Look for these in your work

  • Compare structures
  • Retain evidence without colour

Common mistakes

  • Calling central pallor a nucleus.
  • Treating all white-cell nuclei as identical.
Recall without your notes

What can you explain now?

Which diagram feature supports white-cell identification?

Compare with the explanation

A nucleus within the cell

B and C have nuclei.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Identify the red and white cells with their colours covered.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Biology

Course scope and assessment

780 sequenced lessons provide 2340 guided, independent and application problems in characteristics, classification, cells, organisation, specimen size, membrane transport, biological molecules, enzymes, plant and human nutrition, plant transport, circulatory systems, the heart, blood vessels, blood, disease transmission, body defences, immunity, gas exchange in humans, respiration energy uses and investigations, aerobic respiration, anaerobic respiration and recovery, excretion in humans, coordination and response, sense organs, hormones, homeostasis, tropic responses, drugs, asexual reproduction, sexual reproduction, sexual reproduction in plants, sexual reproduction in humans, sex hormones in humans, sexually transmitted infections, chromosomes, genes and proteins, mitosis, meiosis, monohybrid inheritance, variation, adaptive features, selection, energy flow, food chains and webs, nutrient cycles, population, community, ecosystem, population-growth phases, food supply, habitat destruction, pollution, conservation, biotechnology and genetic modification. 61 of 61 syllabus sections have linked teaching and staged practice. The earlier inheritance overview remains introductory, and the monohybrid pathway develops the relevant Core and Supplement requirements. This is not full programme completion or guaranteed exam readiness. Written practice is self-checked.

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