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IGCSE · Cambridge (CIE) · 0654

Explain separation of chromosome copies into complete daughter complements

A copied A B C complement separates into A B C in each daughter. Equal totals do not rescue a distribution with a missing or duplicated chromosome identity.

Section B16.2 · Cell division

Cell division · Cambridge IGCSE 0654 · B16.2

Mapped to the named 0654 section using teaching from the corresponding single-science course. A 0654-specific review of every Core and Supplement objective is still in progress. Written practice is self-checked; it does not demonstrate supervised laboratory competence or award an official Cambridge grade.

Before you begin

  • Recall chromosomes, genes, chromosome sets, selective gene expression and the distinction between a nucleus and a whole cell.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

What is the expected normal distribution of copied A B C chromosomes?

What you will learn

  • Distribute every chromosome identity
  • Recognise a missing or duplicate product

Original teaching model. Counts and records are stipulated; drawings are schematic.

Explain separation of chromosome copies into complete daughter complementsA copied A B C complement separates into A B C in each daughter. Equal totals do not rescue a distribution with a missing or duplicated chromosome identity.Supplied chromosome identitiesBefore copying: 3 chromosomesABCExact copying before mitosisABC3 replicated chromosomes; 6 DNA moleculesCopies separateduring mitosisABCABCDaughter 1: 3Daughter 2: 3Every original identity in EACHdaughterBoxes are nuclei; cell division usually follows
A copied A B C complement separates into A B C in each daughter. Equal totals do not rescue a distribution with a missing or duplicated chromosome identity.
Division, chromosome count and cell-state key
FeatureMeaning
Normal daughter 1A, B and C
Normal daughter 2A, B and C
Faulty counterexampleA A B / B C C: missing identities
LimitThree labels alone do not establish ploidy

Distribute every chromosome identity

During mitosis, the chromosome copies separate so each daughter nucleus receives the complete complement. In the original three-label model, chromosomes A, B and C have each been copied before division. One copy of A, one of B and one of C must go to each daughter. It is not enough for the total across both products to contain six objects if their distribution is incomplete.

The two products A B C and A B C retain the original three-chromosome list. A hypothetical faulty distribution A A B and B C C also totals six objects, but neither product contains the complete original list. That record is a counterexample to normal accurate mitosis, not an alternative normal method of chromosome maintenance.

Recognise a missing or duplicate product

This model specifies three labelled chromosomes without supplying a diploid or haploid set classification. The number three alone cannot establish its ploidy. It simply lets you check identity, completeness and count. The later diploid model supplies the chromosome-set information needed to show maintenance of both sets as well as the individual chromosome number.

Copies that have separated are counted as daughter chromosomes. The completed daughter nuclei provide the comparable endpoint for the parent-to-product count. Within one not-yet-divided cell during separation, the combined chromosome count is a different question. Do not mix that temporary combined quantity with the maintained number in each final daughter nucleus.

Sources for this lesson

Pause and explain

A A B and B C C total six chromosome objects. Does that establish normal distribution?

Put the idea to work

Worked example

Which daughter lists preserve A B C: A B C / A B C or A A B / B C C?

Show the worked solution
  1. Compare every identity in each product.
  2. Do not rely only on the combined total.

Answer A B C in both daughters preserves the complete complement; the other distribution has missing and duplicate identities.

Try a topic test

Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

Explain the normal separation of copied A B C chromosomes.

Give me a hint

Give every identity to each daughter.

Compare my reasoning
  1. Identify two copies of each original chromosome.
  2. Assign one of each to both products.

One A, one B and one C copy go to each daughter nucleus, giving A B C in both and maintaining the original number three.

Look for these in your work

  • Distribute all identities
  • State the per-daughter number
2 · Independent

Compare correct A B C / A B C with faulty A A B / B C C distributions.

Give me a hint

Check completeness as well as totals.

Compare my reasoning
  1. Count three in each product.
  2. Compare each list with A B C.

Both distributions total six objects, but only A B C / A B C gives every identity to each daughter. A A B lacks C; B C C lacks A.

Look for these in your work

  • Check both daughters
  • Identify the missing entries
3 · Transfer

A three-chromosome diagram has no chromosome-type or set key. Can its number alone show that it is haploid?

Give me a hint

A set must be defined.

Compare my reasoning
  1. Identify that only a total is supplied.
  2. State the absent set or type information.

No. The total three does not establish haploid status without information about a complete set or the chromosome types.

Look for these in your work

  • Distinguish number and ploidy
  • State the evidence limit

Common mistakes

  • A combined total can conceal faulty distribution.
  • A count alone does not specify chromosome sets.
Recall without your notes

What can you explain now?

A A B and B C C total six chromosome objects. Does that establish normal distribution?

Compare with the explanation

No; each daughter has a missing and a duplicated identity

Check every complement separately.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Without your notes, distribute every chromosome identity and recognise a missing or duplicate product. Distinguish nuclear division, chromosome copies and completed daughter cells before opening the solutions.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Sciences — Co-ordinated (Double)

Course scope and assessment

This 2028–2029 pathway maps all 152 detailed subject-content sections in the published 0654 syllabus to original teaching and staged practice. It adapts teaching from the related single-science pathways and excludes clear 0610-only topics such as classification systems, human excretion, tropic responses, food supply, population dynamics, detailed pollution and biotechnology. Some explanations may include wider single-science context. A 0654-specific objective-by-objective review, Core/Supplement audit, human subject-teacher review, supervised laboratory experience and cumulative assessment remain in progress. Written practice is self-checked and does not predict an official grade. The 2025–2027 syllabus has not been reconciled here; choose the 2028–2029 syllabus only.

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