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IGCSE · Cambridge (CIE) · 0653

Compare oxygen and carbon dioxide in inspired and expired air

Use approximate teaching percentages while recognising that expired air still contains oxygen.

Gas exchange in humans · Cambridge IGCSE Combined Science 0653 · B11.1

Cross-referenced to the 2028–2029 0653 section using original teaching from the related single-science courses. A 0653-specific objective-by-objective and Core/Supplement review is in progress. Written practice is self-checked and does not demonstrate supervised laboratory competence or award an official Cambridge grade.

Before you begin

  • Recall proportions and gas mixtures.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

What does 16% mean in a mixture comparison?

What you will learn

  • Compare the two mixtures
  • Read differences carefully

Compare oxygen and carbon dioxide in inspired and expired air

Approximate teaching comparison: inspired O₂ 21%, CO₂ 0.04%; expired O₂ 16%, CO₂ 4%. Expired air remains a mixture containing oxygen.O₂ / %Inspired 21 → expired 16CO₂ / %Inspired 0.04 → expired 4PatternLess O₂; more CO₂
Approximate teaching comparison: inspired O₂ 21%, CO₂ 0.04%; expired O₂ 16%, CO₂ 4%. Expired air remains a mixture containing oxygen. Original teaching model.
Approximate teaching percentages — values vary with conditions
GasInspired / %Expired / %
Oxygen2116
Carbon dioxide0.044

Compare the two mixtures

Inspired air generally contains more oxygen and less carbon dioxide than expired air. For the supplied approximate classroom comparison, oxygen is 21% in inspired air and 16% in expired air; carbon dioxide is 0.04% and 4% respectively. These are example values for describing the pattern, not fixed values for every person, breath or environment.

Both samples remain mixtures of gases. Expired air still contains oxygen, and inspired air already contains some carbon dioxide. A gas-exchange comparison must not turn into the claim that one sample is pure oxygen and the other pure carbon dioxide. In many ordinary comparisons the nitrogen proportion changes little, but the required contrasts here concern oxygen and carbon dioxide.

Read differences carefully

For oxygen, 21 − 16 = 5 percentage points. For carbon dioxide, 4 − 0.04 = 3.96 percentage points. Percentage-point change is the subtraction of percentages, whereas a relative percentage change divides the difference by the starting value; the question must specify which quantity it asks for.

Composition describes proportions rather than the total air volume breathed. A larger breath can contain a larger amount of a gas at the same percentage, so do not infer a measured oxygen amount from percentages alone. The Extended explanation later connects these composition changes to diffusion and cellular respiration.

Sources for this lesson

Pause and explain

Which comparison is correct for the supplied data?

Put the idea to work

Worked example

Find the oxygen difference between 21% inspired and 16% expired air.

Show the worked solution
  1. Subtract the percentages.
  2. Use percentage points for the difference.

Answer 5 percentage points less oxygen in expired air.

Try a topic test

Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

Test this topic →

From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

State the oxygen and carbon-dioxide differences in words.

Give me a hint

Compare inspired with expired air.

Compare my reasoning
  1. Oxygen is lower in expired air.
  2. Carbon dioxide is higher in expired air.

Expired air contains less oxygen and more carbon dioxide than inspired air.

Look for these in your work

  • Compare both gases
  • State the direction
2 · Independent

Calculate the percentage-point differences for oxygen and carbon dioxide using the supplied values.

Give me a hint

Subtract 16 from 21 and 0.04 from 4.

Compare my reasoning
  1. Oxygen difference: 5.
  2. Carbon-dioxide difference: 3.96.

O₂: 5 percentage points lower. CO₂: 3.96 percentage points higher in expired air.

Look for these in your work

  • Calculate both
  • Use percentage points
3 · Transfer

Does 16% oxygen prove that every expired breath contains exactly 160 mL oxygen?

Give me a hint

A proportion needs a total volume.

Compare my reasoning
  1. 160 mL follows only if the relevant total is 1000 mL.
  2. No fixed total volume is given for every breath.

No; the amount depends on total expired volume, and the example percentage is approximate.

Look for these in your work

  • Identify the missing volume
  • Keep the approximation

Common mistakes

  • Saying expired air has no oxygen.
  • Confusing percentage points with relative percent change.
Recall without your notes

What can you explain now?

Which comparison is correct for the supplied data?

Compare with the explanation

Expired air has less O₂ and more CO₂

It matches both changes.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

State both changes and explain why a percentage alone is not an amount.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Science — Combined

Course scope and assessment

This pathway maps all 121 detailed subject-content sections in the published 0653 syllabus for exams in 2028 and 2029. It adapts original lessons from the related single-science pathways and keeps Combined Science's narrower scope: Biology B1–B16, Chemistry C1–C12 and Physics P1–P5. A 0653-specific objective-by-objective review, Core/Supplement audit, human subject-teacher review, supervised laboratory experience and cumulative assessment remain in progress. Written practice is self-checked and does not predict an official grade. The separate 2025–2027 syllabus has not been reconciled here; choose the 2028–2029 syllabus only.

StudyForA · Learn with understanding

Original teaching content and links to official sources. Check your exam year and qualification before using a resource.