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IGCSE · Cambridge (CIE) · 0653

Read the order of peaks on an illustrative hormone graph

Invented relative series: oestrogen sampled maximum day 12; LH maximum day 13; ovulation stipulated day 14; progesterone maximum day 22. Dashed joins guide the eye, and series values are not clinical concentrations.

Sexual reproduction in humans · Cambridge IGCSE Combined Science 0653 · B14.2

Cross-referenced to the 2028–2029 0653 section using original teaching from the related single-science courses. A 0653-specific objective-by-objective and Core/Supplement review is in progress. Written practice is self-checked and does not demonstrate supervised laboratory competence or award an official Cambridge grade.

Before you begin

  • Recall endocrine glands, blood-borne hormones, ovaries, testes, uterine lining, ovulation and implantation.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

Which is the sampled LH maximum in this graph?

What you will learn

  • Read each labelled hormone series independently
  • Connect peak order with the stipulated ovulation event

Original teaching model.

Read the order of peaks on an illustrative hormone graphInvented relative series: oestrogen sampled maximum day 12; LH maximum day 13; ovulation stipulated day 14; progesterone maximum day 22. Dashed joins guide the eye, and series values are not clinical concentrations.Invented non-pregnant cycleFSH · relative model levels051017142128LH · relative model levels051017142128Oestrogen · relative model levels051017142128Progesterone · relative model levels051017142128Model day · ovulation stipulated day 14Dashed joins are guides, not samples
Invented relative series: oestrogen sampled maximum day 12; LH maximum day 13; ovulation stipulated day 14; progesterone maximum day 22. Dashed joins guide the eye, and series values are not clinical concentrations.
Event and hormone key
FeatureMeaning
Oestrogen9 relative units on day 12
LH10 relative units on day 13
OvulationStipulated model day 14
Progesterone9 relative units on day 22
Invented relative levels — series are not matched clinical concentrations
Model dayRelative values
1FSH 4; LH 1; oestrogen 2; progesterone 1
5FSH 3; LH 1; oestrogen 3; progesterone 1
9FSH 2; LH 1; oestrogen 5; progesterone 1
12FSH 2; LH 2; oestrogen 9; progesterone 1
13FSH 4; LH 10; oestrogen 7; progesterone 1
14FSH 3; LH 7; oestrogen 4; progesterone 2
18FSH 1; LH 1; oestrogen 5; progesterone 7
22FSH 1; LH 1; oestrogen 6; progesterone 9
28FSH 4; LH 1; oestrogen 2; progesterone 1

Read each labelled hormone series independently

The original four-panel graph uses invented relative levels at model days 1, 5, 9, 12, 13, 14, 18, 22 and 28. Each panel identifies one hormone. The numbers are arbitrary teaching units, not clinical concentrations. Compare changes within one series; equal plotted numbers in different panels do not mean equal molar concentrations of different hormones.

In this model oestrogen reaches its sampled maximum of 9 units on day 12, LH reaches 10 units on day 13 and ovulation is stipulated on day 14. This order illustrates sustained high pre-ovulation oestrogen preceding the LH surge and release. The graph alone does not prove sustained duration: the teaching caption supplies the pre-ovulation condition. Sparse samples are not continuous measurements.

Connect peak order with the stipulated ovulation event

Progesterone is low before ovulation and rises after it, reaching the sampled maximum of 9 units on day 22. This pattern is consistent with corpus-luteum production after egg release and lining maintenance. FSH has its own labelled pattern, including early follicle stimulation; it should not be identified simply as whichever colour happens to have the tallest peak.

Dashed joins guide the eye between sampled points and are not measured intermediate values. The displayed peaks are sampled maxima, not proof of exact unsampled peak times. The graph illustrates a stated non-pregnant cycle and cannot diagnose ovulation, pregnancy or hormone levels in a real student. Use labels, values and the supplied event marker before giving an explanation.

Sources for this lesson

Pause and explain

Why cannot equal oestrogen and progesterone numbers prove equal concentrations?

Put the idea to work

Worked example

Which sampled maximum comes first, oestrogen or LH?

Show the worked solution
  1. Read oestrogen day 12 and LH day 13.
  2. Compare their stated times rather than line colours.

Answer Oestrogen sampled maximum on day 12 precedes LH sampled maximum on day 13.

Try a topic test

Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

Order oestrogen maximum day 12, LH maximum day 13, ovulation day 14 and progesterone maximum day 22.

Give me a hint

Use the stipulated sampled days and event marker.

Compare my reasoning
  1. Place pre-release signals first.
  2. Place post-release progesterone maximum last.

Oestrogen sampled maximum → LH sampled maximum → stipulated ovulation → progesterone sampled maximum.

Look for these in your work

  • Use correct order
  • Retain sampled/stipulated wording
2 · Independent

Explain why progesterone rises after the stipulated ovulation.

Give me a hint

Connect event with source tissue.

Compare my reasoning
  1. Name remaining follicle forming corpus luteum.
  2. Name progesterone production and lining maintenance.

After ovulation the remaining follicle forms corpus luteum, which produces progesterone supporting lining maintenance.

Look for these in your work

  • Name source origin
  • Give its target role
3 · Transfer

A learner reads a dashed line between days 18 and 22 as a measured personal hormone result. Correct the inference.

Give me a hint

Separate plotting joins from measured samples and real-person data.

Compare my reasoning
  1. Identify joins as visual guides.
  2. Identify all numbers as invented relative model levels.

The dashed join is not a measured intermediate value, and the series is invented teaching data rather than a personal hormone test.

Look for these in your work

  • Give both data limits
  • Avoid a diagnostic claim

Common mistakes

  • Relative units are not clinical concentrations.
  • Dashed joins are not additional measurements.
Recall without your notes

What can you explain now?

Why cannot equal oestrogen and progesterone numbers prove equal concentrations?

Compare with the explanation

Each is an arbitrary relative teaching series

The numbers are not matched clinical concentration units.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Explain read each labelled hormone series independently and connect peak order with the stipulated ovulation event. Follow the event arrows or graph labels before opening the solutions.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Science — Combined

Course scope and assessment

This pathway maps all 121 detailed subject-content sections in the published 0653 syllabus for exams in 2028 and 2029. It adapts original lessons from the related single-science pathways and keeps Combined Science's narrower scope: Biology B1–B16, Chemistry C1–C12 and Physics P1–P5. A 0653-specific objective-by-objective review, Core/Supplement audit, human subject-teacher review, supervised laboratory experience and cumulative assessment remain in progress. Written practice is self-checked and does not predict an official grade. The separate 2025–2027 syllabus has not been reconciled here; choose the 2028–2029 syllabus only.

StudyForA · Learn with understanding

Original teaching content and links to official sources. Check your exam year and qualification before using a resource.