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IGCSE · Cambridge (CIE) · 0653

Identify lymphocytes and phagocytes in diagrams

Use nucleus shape and cytoplasm to distinguish two white-cell examples.

Blood · Cambridge IGCSE Combined Science 0653 · B9.4

Cross-referenced to the 2028–2029 0653 section using original teaching from the related single-science courses. A 0653-specific objective-by-objective and Core/Supplement review is in progress. Written practice is self-checked and does not demonstrate supervised laboratory competence or award an official Cambridge grade.

Before you begin

  • Recall white-cell diagram identification.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

Which two diagrams are white cells?

What you will learn

  • Recognise the lymphocyte example
  • Recognise a phagocyte example without overgeneralising
B lymphocyte: large round nucleus, narrow cytoplasm rim. C neutrophil phagocyte: lobed nucleus. Other phagocyte types can differ; no actual scale is implied.Two white-cell examplesA: mature red cellCentral pallor; no nucleusB: lymphocyteLarge round nucleusC: phagocyte (neutrophil)Lobed nucleus; cytoplasm
B lymphocyte: large round nucleus, narrow cytoplasm rim. C neutrophil phagocyte: lobed nucleus. Other phagocyte types can differ; no actual scale is implied. Original schematic, not to scale.

Recognise the lymphocyte example

In the original comparison, B is a lymphocyte. Its large round nucleus occupies much of the cell, leaving a relatively narrow rim of cytoplasm. That combination supports this example’s identity; do not describe the nucleus as the whole cell or mistake the thin rim for plasma outside it.

A and C supply comparison: A is a mature red cell without a nucleus, and C is a neutrophil, a phagocyte type. The drawn colours are conventions. White-cell identification depends on the supplied morphology and specimen context, not merely being a purple circle.

Recognise a phagocyte example without overgeneralising

C shows a segmented or lobed nucleus and more visible surrounding cytoplasm. These features are characteristic of the neutrophil example used here. Phagocytes engulf pathogens by phagocytosis. Other phagocyte types can have different nucleus shapes, so avoid claiming every phagocyte must look exactly like this drawing.

The syllabus asks learners to recognise lymphocytes and phagocytes in diagrams and photomicrographs. Start with this simplified comparison, then move to the source-confirmed microscope examples. A still diagram of a phagocyte is not itself evidence that engulfing is occurring at that instant; identification and active-function evidence are separate.

Sources for this lesson

Pause and explain

Which identification matches B and C?

Put the idea to work

Worked example

Name B and C and justify each using its nucleus.

Show the worked solution
  1. B has a large round nucleus with a narrow cytoplasm rim.
  2. C is the neutrophil example with a lobed nucleus.

Answer B lymphocyte; C phagocyte (neutrophil example). Their nucleus shapes support the distinction.

Try a topic test

Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

Test this topic →

From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

Identify B and give two supporting features.

Give me a hint

Look at the round nucleus and remaining cytoplasm.

Compare my reasoning
  1. The nucleus is large and round.
  2. A relatively narrow cytoplasm rim remains.

B lymphocyte: large round nucleus and narrow cytoplasm rim.

Look for these in your work

  • Name lymphocyte
  • Use both structural features
2 · Independent

Identify C and state the example’s nucleus feature.

Give me a hint

The drawing is a neutrophil example.

Compare my reasoning
  1. Its nucleus is segmented or lobed.
  2. Neutrophils are phagocytes.

C phagocyte, represented by a neutrophil with a lobed nucleus.

Look for these in your work

  • Name phagocyte
  • Qualify the neutrophil example
3 · Transfer

A different phagocyte has a kidney-shaped nucleus. Must it be rejected because C is lobed?

Give me a hint

One example is not the entire group.

Compare my reasoning
  1. Phagocyte types can differ in nuclear shape.
  2. Use source identity and full morphology for the new specimen.

No; the neutrophil drawing does not define every phagocyte shape. Use the new specimen’s verified identity and features.

Look for these in your work

  • Avoid an absolute shape rule
  • Use specimen evidence

Common mistakes

  • Calling the lymphocyte nucleus the entire cell.
  • Claiming all phagocyte types have identical lobed nuclei.
Recall without your notes

What can you explain now?

Which identification matches B and C?

Compare with the explanation

B lymphocyte; C phagocyte example

B has a large round nucleus; C a lobed one.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Identify B and C without colour and qualify the phagocyte example.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Science — Combined

Course scope and assessment

This pathway maps all 121 detailed subject-content sections in the published 0653 syllabus for exams in 2028 and 2029. It adapts original lessons from the related single-science pathways and keeps Combined Science's narrower scope: Biology B1–B16, Chemistry C1–C12 and Physics P1–P5. A 0653-specific objective-by-objective review, Core/Supplement audit, human subject-teacher review, supervised laboratory experience and cumulative assessment remain in progress. Written practice is self-checked and does not predict an official grade. The separate 2025–2027 syllabus has not been reconciled here; choose the 2028–2029 syllabus only.

StudyForA · Learn with understanding

Original teaching content and links to official sources. Check your exam year and qualification before using a resource.