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A Level · Cambridge (CIE) · 9700

Explain variation from random fertilisation

Explain how random fusion of genetically different gametes creates genetically different individuals.

Passage of information from parents to offspring pathway · 16.1

A Level; Cambridge International Biology 9700, 2028–2030. Written answers are self-checked; this is not practical-skills certification.

Before you begin

  • Genes are DNA sequences that can be inherited; meiosis and fertilisation link parental genomes.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

What does random fertilisation combine?

What you will learn

  • Explain that fertilisation randomly combines gametes
  • Relate genetically different gametes to variation among offspring

Original teaching model. Counts, source combinations and sample records are stipulated; drawings are schematic.

Explain how reduction and fertilisation maintain the diploid complementReduction before fusion allows the usual two-set complement to be restored.Supplied diploid animal model: n = 20Precursor A2n = 40Precursor B2n = 40Meiosis in each gamete-productionrouteOne gameten = 20Other gameten = 20Later fertilisationZygote nucleusn + n = 2n = 40Selected gametes from their ownprecursor routes
Reduction before fusion allows the usual two-set complement to be restored.
Chromosome sets, combinations and evidence key
FeatureMeaning
Normal precursorn = 20; diploid complement 40
Normal gametes20 in each haploid nucleus
Normal fertilisation20 + 20 = 40 in one zygote nucleus
Counterfactual unreduced fusion40 + 40 = 80; no viability inference

Build the genetic explanation

Meiosis can produce genetically different gametes through independent assortment and crossing over. At fertilisation, any one genetically different gamete may fuse with any compatible gamete from another parent. The random combination produces a new diploid genotype, adding variation to that created during meiosis. It does not guarantee that every possible genotype is equally likely if gamete production or survival differs.

Check the evidence and limits

Random fertilisation is a source of genetic variation, not a predictable one-to-one pairing of matching gametes. Probability describes expected chances over many events; it does not identify the genotype of a particular offspring.

Pause and explain

If each of two parents can produce many genetically different gametes, explain why the number of possible offspring genotypes can be large.

Put the idea to work

Worked example

Why can two siblings from the same parents have different allele combinations?

Show the worked solution
  1. Each parent produces genetically varied gametes.
  2. Fertilisation randomly combines one gamete from each parent.

Answer Different genetically varied gametes can fuse at fertilisation, giving siblings different combinations of parental alleles.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

Explain how independent assortment and random fertilisation contribute to offspring variation.

Give me a hint

Set out the alleles or steps before deciding the outcome.

Compare my reasoning
  1. Meiosis produces different gamete combinations.
  2. Fertilisation combines one gamete from each parent at random.

Independent assortment produces gametes with different combinations of parental homologues. Random fertilisation combines one gamete from each parent, creating new diploid allele combinations.

Look for these in your work

  • Genetic terms used correctly
  • Steps linked
2 · Independent

A couple has three children with different genotypes. Does this contradict Mendelian probability? Explain.

Give me a hint

Use the given evidence and state your assumptions.

Compare my reasoning
  1. Each fertilisation is a separate random event.
  2. Probabilities do not prescribe a fixed sequence of outcomes.

No. Genetic probabilities describe expected proportions over many independent events, not a fixed order or guaranteed composition of a small family.

Look for these in your work

  • Prediction or interpretation supported
  • Limits stated
3 · Transfer

If each of two parents can produce many genetically different gametes, explain why the number of possible offspring genotypes can be large.

Give me a hint

Apply the inheritance or gene-control model to the new context.

Compare my reasoning
  1. Each gamete can combine with many possible gametes from the other parent.
  2. Different combinations produce different zygote genotypes.

Each of many gamete types from one parent can fuse with many types from the other, producing numerous possible zygote genotypes.

Look for these in your work

  • Model applied accurately
  • Unsupported certainty avoided

Common mistakes

  • Claiming siblings inherit identical gametes
  • Treating probability ratios as guaranteed family outcomes
Recall without your notes

What can you explain now?

What does random fertilisation combine?

Compare with the explanation

One gamete from each parent

The combination restores diploidy and creates a new genotype.

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Make it stick

How does random fertilisation add to the variation generated by meiosis?

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Biology

Course scope and assessment

Two hundred and fifty-nine new lessons map every published learning outcome in Cambridge International Biology 9700 Topics 1–19 for exams 2028–2030. Each topic lesson includes guided, independent and transfer practice. Fifteen additional practical-assessment lessons provide online preparation for Paper 3 and Paper 5 practical assessment skills. Online Paper 3 lessons cannot provide supervised laboratory competence. Full timed cumulative exam practice and human subject-teacher review remain outstanding, so this is not exam-readiness evidence.

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Original teaching content and links to official sources. Check your exam year and qualification before using a resource.