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A Level · Cambridge (CIE) · 9700

Trace chromosome behaviour through meiosis

Describe the main chromosome, spindle, nuclear-envelope and cell-surface events in meiosis I and II.

Passage of information from parents to offspring pathway · 16.1

A Level; Cambridge International Biology 9700, 2028–2030. Written answers are self-checked; this is not practical-skills certification.

Before you begin

  • Genes are DNA sequences that can be inherited; meiosis and fertilisation link parental genomes.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

What separates at anaphase II?

What you will learn

  • Describe the main stages of meiosis I and meiosis II
  • Relate spindle attachment, chromosome movement, nuclear envelopes and cytokinesis to each division

Original teaching model. Counts, source combinations and sample records are stipulated; drawings are schematic.

Distinguish meiosis mitosis and fertilisation using the supplied nuclear evidenceCompare the event, starting complement and per-nucleus outcome together.Normal diploid mitosis6 → 6 in each daughter; maintainedcomplementNormal meiotic reduction6 → 3 in each final product; onecomplete setNormal fertilisation3 + 3 → 6 in the zygote nucleusEvidence limitSix alone does not establish whichevent occurred
Compare the event, starting complement and per-nucleus outcome together.
Chromosome sets, combinations and evidence key
FeatureMeaning
Normal diploid mitosis6 → 6 in each daughter; maintained complement
Normal meiotic reduction6 → 3 in each final product; one complete set
Normal fertilisation3 + 3 → 6 in the zygote nucleus
Evidence limitSix alone does not establish which event occurred

Build the genetic explanation

In prophase I, homologous chromosomes pair; the nuclear envelope breaks down and a spindle forms. At metaphase I, homologous pairs align at the equator. In anaphase I, homologues move to opposite poles while centromeres remain intact and sister chromatids stay together. Telophase I may reform nuclear envelopes and cell division produces two haploid nuclei with replicated chromosomes. In prophase II a new spindle forms; chromosomes align singly at metaphase II; centromeres divide and sister chromatids separate at anaphase II; and telophase II reforms nuclei. Cytokinesis produces four haploid nuclei.

Check the evidence and limits

The syllabus expects the eight main stages but not subdivisions of prophase I. In plant cells, cytokinesis forms a cell plate; in animal cells, the surface membrane constricts. Do not separate sister chromatids in anaphase I.

Pause and explain

A plant meiosis diagram shows a plate forming across the cell at the end of a division. Explain the structure and stage context.

Put the idea to work

Worked example

At anaphase I, which structures move apart and which remain joined?

Show the worked solution
  1. Homologous chromosomes separate.
  2. Centromeres do not divide until meiosis II.

Answer Homologous chromosomes move to opposite poles; sister chromatids remain joined at their centromeres.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

Compare chromosome movement at anaphase I and anaphase II.

Give me a hint

Set out the alleles or steps before deciding the outcome.

Compare my reasoning
  1. Homologues separate in meiosis I.
  2. Centromeres divide and sister chromatids separate in meiosis II.

At anaphase I homologous chromosomes move apart while sister chromatids remain attached. At anaphase II centromeres divide and sister chromatids separate.

Look for these in your work

  • Genetic terms used correctly
  • Steps linked
2 · Independent

A stage shows homologous pairs lined up at the equator with spindle fibres attached. Identify the stage and one event that follows.

Give me a hint

Use the given evidence and state your assumptions.

Compare my reasoning
  1. Pairs, not single chromosomes, align in meiosis I.
  2. Homologues separate next.

It is metaphase I. In anaphase I, homologous chromosomes move to opposite poles.

Look for these in your work

  • Prediction or interpretation supported
  • Limits stated
3 · Transfer

A plant meiosis diagram shows a plate forming across the cell at the end of a division. Explain the structure and stage context.

Give me a hint

Apply the inheritance or gene-control model to the new context.

Compare my reasoning
  1. The cell plate forms during cytokinesis in plant cells.
  2. It separates daughter cytoplasm after nuclear division.

The cell plate forms during cytokinesis in a plant cell, partitioning the cytoplasm after a meiotic nuclear division.

Look for these in your work

  • Model applied accurately
  • Unsupported certainty avoided

Common mistakes

  • Separating sister chromatids in meiosis I
  • Describing anaphase II as separation of homologues
Recall without your notes

What can you explain now?

What separates at anaphase II?

Compare with the explanation

Sister chromatids

Centromeres divide and sister chromatids move to opposite poles.

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Make it stick

What separates in meiosis I, and what separates in meiosis II?

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Biology

Course scope and assessment

Two hundred and fifty-nine new lessons map every published learning outcome in Cambridge International Biology 9700 Topics 1–19 for exams 2028–2030. Each topic lesson includes guided, independent and transfer practice. Fifteen additional practical-assessment lessons provide online preparation for Paper 3 and Paper 5 practical assessment skills. Online Paper 3 lessons cannot provide supervised laboratory competence. Full timed cumulative exam practice and human subject-teacher review remain outstanding, so this is not exam-readiness evidence.

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Original teaching content and links to official sources. Check your exam year and qualification before using a resource.