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IGCSE · Cambridge (CIE) · 0973

Read chromosome pairing evidence without equating pairs with identical genes

Corresponding autosome positions can have different allele forms. Changing a form does not change chromosome-set counts, and the usual XY sex-chromosome pair is not two identical copies.

Chromosomes and genes · Cambridge IGCSE 0973 · B16.1
Exam scope and assessment notes

Mapped to the named 0973 section using teaching from the corresponding single-science course. A 0973-specific review of every Core and Supplement objective is still in progress. Written practice is self-checked; it does not demonstrate supervised laboratory competence or award an official Cambridge grade. This qualification reports two grades on the 9–1 scale; confirm the entry route for your zone and exam series.

Before you begin

  • Recall the nucleus, DNA base pairing, gametes, fertilisation, enzymes, membrane carriers and chemical synapses.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

What can corresponding positions on a supplied autosome pair show?

What you will learn

  • Use supplied corresponding types to recognise a pair arrangement
  • Retain allele and sex-chromosome differences

Original teaching model. Counts and records are stipulated; drawings are schematic.

Read chromosome pairing evidence without equating pairs with identical genesCorresponding autosome positions can have different allele forms. Changing a form does not change chromosome-set counts, and the usual XY sex-chromosome pair is not two identical copies.Stipulated three-type chromosome modelTwo sets: each has types 1, 2 and 3Set 112A3Set 212a36 individuals · 3 corresponding pairsRods represent unreplicated individuals
Corresponding autosome positions can have different allele forms. Changing a form does not change chromosome-set counts, and the usual XY sex-chromosome pair is not two identical copies.
Information, material and count key
FeatureMeaning
Autosome correspondenceSupplied type and gene-position key
Possible information differenceDifferent allele forms
Unchanged small-model countsTwo sets, three pairs, six individuals
Sex-pair distinctionX and Y are not identical copies

Use supplied corresponding types to recognise a pair arrangement

A pair arrangement groups two representatives of the same supplied chromosome type in the simple autosome model. Corresponding positions can carry the same gene identities without carrying the same allele forms. Pairing is therefore a relationship between supplied chromosome types, not a statement that every DNA base on both objects must be identical.

The original small model shows three paired autosome types, with one contribution from each stipulated gamete set. At the marked gene position on type 2, one chromosome carries form A and the other form a. There are still three chromosome pairs and six individuals; changing the allele labels does not change the number of sets or create an extra whole chromosome.

Retain allele and sex-chromosome differences

The usual human count adds a sex-chromosome pair to 22 autosome pairs. In the XX/XY model, X and Y are not identical copies and differ in information. Keep this distinction when using the syllabus shorthand about pairs: an autosome pairing key should not be used to claim every sex-chromosome pair has identical shapes, sizes or genes.

A drawn resemblance is not a complete chromosome-identification test. The practice supplies a key giving corresponding types and explicitly labels unreplicated individuals, so counts can be checked. An unkeyed image alone may not establish exact type, genotype or a diagnosis. Keep what the key supplies separate from observations it does not support.

Sources for this lesson

Pause and explain

What remains unchanged when one allele label changes on the same six objects?

Put the idea to work

Worked example

Does changing one allele label from A to a add a chromosome pair?

Show the worked solution
  1. Retain the same chromosome objects and positions.
  2. Identify the changed information form rather than a new chromosome.

Answer No. The allele form changes in the model, but the chromosome objects, pair count and set number remain the same.

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Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

Interpret A and a at a corresponding position on a supplied autosome pair.

Give me a hint

Use identity, form and pair count separately.

Compare my reasoning
  1. Keep one gene identity at that position.
  2. Identify two forms on the same chromosome pair.

The pair carries the same supplied gene identity at corresponding positions but different allele forms A and a; it remains one chromosome pair.

Look for these in your work

  • Distinguish gene and form
  • Keep pair count
2 · Independent

A three-pair six-individual model changes only one allele label. Count sets pairs and individuals after the change.

Give me a hint

No chromosome object has been added or removed.

Compare my reasoning
  1. Retain two supplied sets.
  2. Retain three pairs and six individuals.

The model still has two sets, three pairs and six individual chromosomes; only the supplied information form changed.

Look for these in your work

  • Give all counts
  • Explain unchanged objects
3 · Transfer

Evaluate the claim that a usual human XY sex-chromosome pair must contain identical information because it is called a pair.

Give me a hint

Use the specific X/Y distinction.

Compare my reasoning
  1. Identify X and Y as different sex chromosomes in the model.
  2. Reject identical information from the pair label.

The claim is inaccurate: X and Y differ in size and information in the specified model, so calling them a sex-chromosome pair does not make them identical copies.

Look for these in your work

  • Name the X/Y distinction
  • Reject the identical-copy inference

Common mistakes

  • Allele labels do not create whole chromosome objects.
  • X and Y should not be called identical copies.
Recall without your notes

What can you explain now?

What remains unchanged when one allele label changes on the same six objects?

Compare with the explanation

Three pairs and six individuals in the supplied model

Information labels do not add objects.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Explain use supplied corresponding types to recognise a pair arrangement and retain allele and sex-chromosome differences. Use the stated cell, chromosome sets and information pathway before opening the solutions.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Sciences — Co-ordinated (9-1)

Course scope and assessment

This 9–1 pathway maps all 152 detailed subject-content sections in the published 0973 syllabus for exams in 2028 and 2029. The course map follows the same 2028–2029 section codes as Cambridge's A*–G 0654 syllabus, while keeping 0973's grading and entry rules separate. It adapts lessons from the related single-science courses and excludes clear single-science-only topics. A 0973-specific objective-by-objective review, Core/Supplement audit, human subject-teacher review, supervised laboratory experience and cumulative assessment remain in progress. Written practice is self-checked and does not predict an official grade. The separate 2025–2027 syllabus has not been reconciled here. Cambridge lists 0973 only in a limited number of administrative zones: June in zone 3 and centres in Oman and the UAE; November in zone 3 only. Confirm entry with your centre.

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