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IGCSE · Cambridge (CIE) · 0973

Review Supplement selection and resistance

Integrate adaptation, phenotype records, bacterial resistance and the two selection processes.

Selection · Cambridge IGCSE 0973 · B17.2
Exam scope and assessment notes

Mapped to the named 0973 section using teaching from the corresponding single-science course. A 0973-specific review of every Core and Supplement objective is still in progress. Written practice is self-checked; it does not demonstrate supervised laboratory competence or award an official Cambridge grade. This qualification reports two grades on the 9–1 scale; confirm the entry route for your zone and exam series.

Before you begin

  • Use the supplied biological context. Resistance examples are educational and not medical advice or lab protocols.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

Which statement correctly describes population adaptation?

What you will learn

  • Explain adaptation as a population process over generations
  • Evaluate a resistance record and compare selection mechanisms

Original selection schematic. Population counts and scenarios are supplied teaching models; they are not field observations.

Review Supplement selection and resistanceOriginal schematic for this worked context. Trait, population and selection claims use only the supplied assumptions; stage labels are not measurements of every individual.Review Supplement selection and resistance1Populationdescribe change across generations, not anindividual changing by need.2Recordsuse stage-specific denominators and identifyphenotype data.3Compareenvironment-driven reproduction versus humanchoice of breeding parents.
Original schematic for this worked context. Trait, population and selection claims use only the supplied assumptions; stage labels are not measurements of every individual.
Selection evidence key
Stage or recordMeaning
AdaptationPopulation; many generations
ResistanceBacteria; specific drug context
Natural selectionEnvironmental effects on reproductive chance
Artificial selectionHuman choice, crossing and offspring selection

Explain adaptation as a population process over generations

Adaptation by natural selection describes populations becoming more suited to their environment over many generations. Link inherited variation with resource competition and differential reproductive outcomes. Individuals do not acquire needed alleles because of a short-term challenge; descendants inherit alleles through reproduction.

Resistance is a bacterial example. A population may contain variants with different responses to a particular antibiotic. The drug context can select for bacteria more likely to survive; resistant bacteria that reproduce can pass resistance information to descendants. Resistance belongs to germs, not to a person, and the model does not prescribe treatment.

Evaluate a resistance record and compare selection mechanisms

For numerical records, calculate each phenotype fraction using the total at that stage. The resistant proportion can rise even when resistant counts fall. A phenotype fraction is not automatically an allele frequency. Keep the origin of variation, the selection event, subsequent reproduction and any horizontal transfer distinct.

Natural and artificial selection both rely on variation and inheritance. In natural selection, environmental conditions affect reproductive chances. In artificial selection, people choose desirable parents, cross them and select offspring. State which mechanism a question supports and leave later syllabus areas, practical competence and cumulative assessment within their explicit limits.

Sources for this lesson

Pause and explain

Which pair correctly identifies the two selection mechanisms?

Put the idea to work

Worked example

A bacterial dataset gives 10 resistant and 90 susceptible before exposure; 8 and 9 survive. A separate crop programme deliberately chooses parents for seed size. Calculate the resistant-share change and distinguish the processes.

Show the worked solution
  1. Calculate 10/100 before and 8/17 after.
  2. The bacterial drug context is natural selection; deliberate crop parent choice is artificial selection.

Answer The resistant fraction rises from 10% to about 47.1% while its count falls from 10 to 8. The bacterial case illustrates selection by a drug context; deliberate crop parent choice is artificial selection. The figures are stipulated phenotype counts, not allele frequencies.

Try a topic test

Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

For 10 resistant, 90 susceptible before and 8, 9 survivors, calculate the resistant share at both stages and state the absolute count change.

Give me a hint

Use totals 100 and 17.

Compare my reasoning
  1. Before 10%; after 8/17≈47.1%.
  2. Resistant count changes 10→8, a fall of 2.

The share rises from 10% to about 47.1%, while the resistant count falls by 2; the data are stipulated phenotype groups.

Look for these in your work

  • Correct stage percentages
  • Absolute count change
2 · Independent

A wild plant population becomes more drought-suited over many generations; farmers separately choose drought-tolerant crop parents. Compare.

Give me a hint

Separate environmental effects from deliberate breeding decisions.

Compare my reasoning
  1. The wild-population case is natural selection if inheritance and differential reproduction are supported.
  2. The crop programme is artificial selection because people choose parents.

Both involve inheritance and reproduction; the primary selection pressure differs between environment and human parent choice.

Look for these in your work

  • Correct classification
  • Shared basis and distinction
3 · Transfer

A report shows more resistant bacteria after an antibiotic, but gives no pre-exposure sample, genotype count or comparison group. State one observation and two limits.

Give me a hint

Keep observed detection separate from origin, selection and allele-frequency claims.

Compare my reasoning
  1. Resistant bacteria were detected at the later stage.
  2. No baseline means the change cannot be quantified.

The observation is that resistance was detected later; the record cannot quantify a before–after shift or establish when resistance arose, nor calculate allele frequency without genotype data.

Look for these in your work

  • Observation stated
  • Two limits

Common mistakes

  • Using the same denominator at both stages
  • Calling the antibiotic artificial selection by itself
  • Treating phenotype counts as allele counts
Recall without your notes

What can you explain now?

Which pair correctly identifies the two selection mechanisms?

Compare with the explanation

Environment affects reproduction; people choose breeding parents

The selector and process differ.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Without your notes, explain adaptation as a population process over generations and evaluate a resistance record and compare selection mechanisms. Explain the mechanism, use the given population or breeding records and state what the evidence does not establish.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Sciences — Co-ordinated (9-1)

Course scope and assessment

This 9–1 pathway maps all 152 detailed subject-content sections in the published 0973 syllabus for exams in 2028 and 2029. The course map follows the same 2028–2029 section codes as Cambridge's A*–G 0654 syllabus, while keeping 0973's grading and entry rules separate. It adapts lessons from the related single-science courses and excludes clear single-science-only topics. A 0973-specific objective-by-objective review, Core/Supplement audit, human subject-teacher review, supervised laboratory experience and cumulative assessment remain in progress. Written practice is self-checked and does not predict an official grade. The separate 2025–2027 syllabus has not been reconciled here. Cambridge lists 0973 only in a limited number of administrative zones: June in zone 3 and centres in Oman and the UAE; November in zone 3 only. Confirm entry with your centre.

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