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IGCSE · Cambridge (CIE) · 0654

Identify vesicles gap and receptors in a published synapse image

Translate the unchanged source labels into the syllabus structures.

Coordination and response · Cambridge IGCSE 0654 · B13.1

Mapped to the named 0654 section using teaching from the corresponding single-science course. A 0654-specific review of every Core and Supplement objective is still in progress. Written practice is self-checked; it does not demonstrate supervised laboratory competence or award an official Cambridge grade.

Before you begin

  • Recall cell membranes, diffusion, sensitivity and the difference between cells, tissues and organs.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

What does Synaptic cleft name in this source?

What you will learn

  • Read the enlarged axon-terminal view
  • Separate the source illustration from a scale measurement

Identify vesicles gap and receptors in a published synapse image

Published chemical synapse illustration with vesicles in the upper presynaptic axon terminal, green neurotransmitter molecules, cleft and receptor-bearing channels on the lower postsynaptic membrane.
OpenStax Anatomy and Physiology · Young et al., version 8.25 (2016) · CC BY 4.0 · Original licence record · Source image unchanged; displayed responsively. Open full-size image

Unchanged OpenStax chemical-synapse illustration. Cleft means gap; receiving receptor-bearing channels are shown on the postsynaptic membrane. The inset arrow indicates enlargement.

Enlarge image for inspection

Scroll across the source to trace its leaders and gap bracket. Try identification before opening the key.

Published chemical synapse illustration with vesicles in the upper presynaptic axon terminal, green neurotransmitter molecules, cleft and receptor-bearing channels on the lower postsynaptic membrane.
Check the identification key

Synaptic vesicles: round compartments within the upper terminal. Neurotransmitters: green particles in vesicles and cleft. Synaptic cleft: gap between membranes. Ligand-gated channels with receptors for neurotransmitters: turquoise receptor-bearing proteins on the lower postsynaptic membrane. The grey inset arrow marks enlargement, not an electrical impulse crossing the gap.

Read the enlarged axon-terminal view

The published OpenStax image shows an enlarged chemical synapse. The upper bulb is labelled Axon terminal and belongs to the presynaptic neurone. The lower receiving cell is labelled Postsynaptic neuron. The small whole-cell inset and grey magnification arrow locate the enlarged detail; that broad arrow is not an electrical impulse crossing the gap.

The printed Synaptic vesicles leaders end on round membrane-bounded compartments in the upper terminal. Neurotransmitters points to green particles inside a vesicle and in the space below. These are the molecules contained by the vesicles and released into the junction. The source shapes and colours make the container and contents distinguishable but do not establish their real relative size.

Separate the source illustration from a scale measurement

The printed Synaptic cleft bracket spans the space between the upper terminal and lower membrane. Cleft is the source name for the synaptic gap. The longer label Ligand-gated channels with receptors for neurotransmitters points to a turquoise protein shape in the postsynaptic membrane. These receptor-bearing proteins provide the receiving binding sites needed in the syllabus account.

The image illustrates a common receptor-bearing channel model; it does not establish that every receptor in all synapses must be this channel type. It also does not identify these two cells as sensory, relay or motor neurones. Read the actual labels and connected regions rather than inventing those roles from shape alone. Try the identification before opening the separate key, and enlarge the unchanged image to follow the small leaders.

Sources for this lesson

Pause and explain

Where does the receiving receptor-bearing channel leader end?

Put the idea to work

Worked example

Find vesicles, neurotransmitter, gap and receiving receptor proteins in the source image.

Show the worked solution
  1. Follow the vesicle and neurotransmitter leaders in the upper terminal.
  2. Read the cleft bracket and receptor-bearing channel leader on the lower membrane.

Answer Round upper compartments are vesicles; green particles are neurotransmitter; the cleft is the gap; the lower receptor-bearing channel proteins provide binding sites.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

Identify the printed source labels that establish the required synaptic structures.

Give me a hint

Match the source wording to the syllabus names.

Compare my reasoning
  1. Synaptic vesicles contain the green neurotransmitter molecules.
  2. Synaptic cleft is the gap; receptor-bearing channels are on the postsynaptic membrane.

Synaptic vesicles containing neurotransmitters; Synaptic cleft for the gap; Ligand-gated channels with receptors for neurotransmitters for the receiving receptor proteins.

Look for these in your work

  • Match all required features
  • Keep the original source labels
2 · Independent

Explain the difference between a round vesicle and a small green particle in the source view.

Give me a hint

Container and contained chemical are different.

Compare my reasoning
  1. The round membrane-bound structure is a vesicle.
  2. The green particle represents a neurotransmitter molecule.

The vesicle is a membrane-bounded container; the green particles represent neurotransmitter molecules stored inside or released from it.

Look for these in your work

  • Separate container and contents
  • Use the actual image key
3 · Transfer

Does the grey arrow from the whole-cell inset prove an electrical impulse jumps across the cleft?

Give me a hint

Read its purpose as enlargement of detail.

Compare my reasoning
  1. It connects the inset location with the magnified terminal view.
  2. Chemical transmission across the gap uses neurotransmitter molecules.

No. The grey arrow indicates magnification of a region; it is not evidence of an electrical impulse jumping across the cleft.

Look for these in your work

  • Read magnification correctly
  • Retain chemical gap transmission

Common mistakes

  • Treating the grey enlargement arrow as gap-crossing electrical travel.
  • Calling every synaptic receptor the same channel type.
Recall without your notes

What can you explain now?

Where does the receiving receptor-bearing channel leader end?

Compare with the explanation

On the postsynaptic membrane

That is the next cell’s receiving side.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Locate the required structures in the published image and explain the magnification arrow.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Sciences — Co-ordinated (Double)

Course scope and assessment

This 2028–2029 pathway maps all 152 detailed subject-content sections in the published 0654 syllabus to original teaching and staged practice. It adapts teaching from the related single-science pathways and excludes clear 0610-only topics such as classification systems, human excretion, tropic responses, food supply, population dynamics, detailed pollution and biotechnology. Some explanations may include wider single-science context. A 0654-specific objective-by-objective review, Core/Supplement audit, human subject-teacher review, supervised laboratory experience and cumulative assessment remain in progress. Written practice is self-checked and does not predict an official grade. The 2025–2027 syllabus has not been reconciled here; choose the 2028–2029 syllabus only.

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