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IGCSE · Cambridge (CIE) · 0610

Explain different cell functions through selective gene expression

Most body cells share genes but can express different subsets to make different needed proteins. Gene presence is distinct from current use; nucleus-free cell exceptions and variable expression remain explicit.

Chromosomes, genes and proteins pathway · 17.1

Extended only (Supplement); Biology 0610, 2026–2028. Use the stated specimen features and evidence. Diagrams are schematic. Written practice is self-checked

Before you begin

  • Recall the nucleus, DNA base pairing, gametes, fertilisation, enzymes, membrane carriers and chemical synapses.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

How can cells with the same supplied genes have different functions?

What you will learn

  • Separate genes present from genes currently used
  • Connect required proteins with specialised cell function

Original teaching model. Counts and records are stipulated; drawings are schematic.

Explain different cell functions through selective gene expressionMost body cells share genes but can express different subsets to make different needed proteins. Gene presence is distinct from current use; nucleus-free cell exceptions and variable expression remain explicit.Available informationShared supplied gene setSelective useDifferent genes expressedProductProteins needed for cell functionQualifierMost body cells, not every cellwithout exception
Most body cells share genes but can express different subsets to make different needed proteins. Gene presence is distinct from current use; nucleus-free cell exceptions and variable expression remain explicit.
Information, material and count key
FeatureMeaning
Available informationShared supplied gene set
Selective useDifferent genes expressed
ProductProteins needed for cell function
QualifierMost body cells, not every cell without exception

Separate genes present from genes currently used

Most body cells in an organism contain the same genes, yet different cell types have different functions. Many genes present in a particular cell are not expressed there because the cell makes the particular proteins it needs. Gene expression means using gene information to produce its functional product; in this protein-coding pathway the relevant product is a protein.

A cell making enzyme E and another cell making receptor R need not have completely different DNA gene collections. Their different production can arise through different genes being expressed. Selective use of information is not the same as deleting every unused gene. This helps explain specialisation while keeping the distinction between available information and current function.

Connect required proteins with specialised cell function

The phrase most body cells matters. A mature mammalian red blood cell lacks a nucleus, so do not make an exception-free claim that every body cell has an identical nuclear gene collection. The stated model compares nucleated body cells with the same supplied gene set; it does not attempt to describe every mutation, specialised DNA change or cell exception.

The original expression switch is a teaching model showing genes present and products currently made as separate rows. It does not imply expression is always a simple permanent on/off state; amounts and conditions can vary. A missing product observation also does not, by itself, prove the DNA gene is absent or that the protein was never made earlier.

Pause and explain

What is wrong with every body cell always has the same nuclear genes?

Put the idea to work

Worked example

Why can two nucleated cells with the same supplied genes make different proteins?

Show the worked solution
  1. Retain the shared gene collection.
  2. Explain different genes being expressed for cell needs.

Answer They can express different genes and make different required proteins even though the supplied DNA gene collection is the same.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

Explain different protein production in two nucleated cells with the same supplied gene set.

Give me a hint

Use selective expression and different protein needs.

Compare my reasoning
  1. Keep the shared DNA information.
  2. Use different genes to make the needed proteins.

The cells can contain the same genes but express different subsets, producing the proteins needed for their different functions.

Look for these in your work

  • Retain gene presence
  • Explain selective use
2 · Independent

A gene is present but not currently expressed in a stipulated cell. Has it necessarily been deleted?

Give me a hint

Presence and use are different.

Compare my reasoning
  1. Retain the supplied DNA gene presence.
  2. Distinguish non-expression from removal.

No. The gene remains present in the supplied DNA record but is not currently being used in that cell; non-expression is not deletion.

Look for these in your work

  • Keep the given presence
  • Separate use and removal
3 · Transfer

Evaluate an all-body-cells statement using a mature mammalian red blood cell.

Give me a hint

The syllabus says most, not every.

Compare my reasoning
  1. Identify the mature cell’s lack of a nucleus.
  2. Reject the exception-free nuclear-gene claim.

A mature mammalian red blood cell has no nucleus, so an exception-free claim about every body cell’s identical nuclear genes is inaccurate; the syllabus uses most body cells.

Look for these in your work

  • Identify the exception
  • Retain the correct qualifier

Common mistakes

  • Unused information is not necessarily deleted.
  • Most body cells is not an exception-free every-cell statement.
Recall without your notes

What can you explain now?

What is wrong with every body cell always has the same nuclear genes?

Compare with the explanation

Most body cells allows exceptions such as nucleus-free mature mammalian red blood cells

The qualifier matters.

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Make it stick

Explain separate genes present from genes currently used and connect required proteins with specialised cell function. Use the stated cell, chromosome sets and information pathway before opening the solutions.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

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Course scope and assessment

780 sequenced lessons provide 2340 guided, independent and application problems in characteristics, classification, cells, organisation, specimen size, membrane transport, biological molecules, enzymes, plant and human nutrition, plant transport, circulatory systems, the heart, blood vessels, blood, disease transmission, body defences, immunity, gas exchange in humans, respiration energy uses and investigations, aerobic respiration, anaerobic respiration and recovery, excretion in humans, coordination and response, sense organs, hormones, homeostasis, tropic responses, drugs, asexual reproduction, sexual reproduction, sexual reproduction in plants, sexual reproduction in humans, sex hormones in humans, sexually transmitted infections, chromosomes, genes and proteins, mitosis, meiosis, monohybrid inheritance, variation, adaptive features, selection, energy flow, food chains and webs, nutrient cycles, population, community, ecosystem, population-growth phases, food supply, habitat destruction, pollution, conservation, biotechnology and genetic modification. 61 of 61 syllabus sections have linked teaching and staged practice. The earlier inheritance overview remains introductory, and the monohybrid pathway develops the relevant Core and Supplement requirements. This is not full programme completion or guaranteed exam readiness. Written practice is self-checked.

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