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IGCSE · Cambridge (CIE) · 0610

Monohybrid inheritance

Use alleles and probability to predict possible offspring without treating ratios as guarantees.

What you will learn

  • Distinguish genotype from phenotype.
  • Construct a one-gene cross.

Separate genetic information from its expression

A genotype is an organism's allele combination for the gene considered. A phenotype is the expressed characteristic, influenced by genotype and sometimes the environment. Under complete dominance, a heterozygote shows the dominant phenotype.

Homozygous means two identical alleles; heterozygous means two different alleles. A dominant allele is not necessarily more common in a population.

List gametes before combining them

Each gamete receives one allele for the gene. A heterozygote can produce either allele. Combine each parent's possible gametes in a Punnett square and count the relevant genotype or phenotype.

Ratios describe probabilities across offspring, not a promise that every group of four contains exactly one recessive individual.

Put the idea to work

Worked example

Two heterozygous plants Aa and Aa are crossed. A is completely dominant. Find the probability of the recessive phenotype.

Show the worked solution
  1. Each parent produces A or a gametes.
  2. The four equally likely combinations are AA, Aa, aA and aa.
  3. Only aa expresses the recessive phenotype under complete dominance.

Answer 1/4, or 25%

Common mistakes

  • A genotype ratio and a phenotype ratio can differ.
  • Dominance does not mean an allele is stronger or more frequent.
Recall without your notes

What can you explain now?

Cross Aa with aa. What fraction of offspring is expected to be Aa?

Compare with the explanation

1/2

The first parent contributes A or a with equal probability; the second always contributes a.

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Course scope and assessment

780 sequenced lessons provide 2340 guided, independent and application problems in characteristics, classification, cells, organisation, specimen size, membrane transport, biological molecules, enzymes, plant and human nutrition, plant transport, circulatory systems, the heart, blood vessels, blood, disease transmission, body defences, immunity, gas exchange in humans, respiration energy uses and investigations, aerobic respiration, anaerobic respiration and recovery, excretion in humans, coordination and response, sense organs, hormones, homeostasis, tropic responses, drugs, asexual reproduction, sexual reproduction, sexual reproduction in plants, sexual reproduction in humans, sex hormones in humans, sexually transmitted infections, chromosomes, genes and proteins, mitosis, meiosis, monohybrid inheritance, variation, adaptive features, selection, energy flow, food chains and webs, nutrient cycles, population, community, ecosystem, population-growth phases, food supply, habitat destruction, pollution, conservation, biotechnology and genetic modification. 61 of 61 syllabus sections have linked teaching and staged practice. The earlier inheritance overview remains introductory, and the monohybrid pathway develops the relevant Core and Supplement requirements. This is not full programme completion or guaranteed exam readiness. Written practice is self-checked.

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