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IGCSE · Cambridge (CIE) · 0610

Explain why normal mitosis maintains the chromosome number

Normal mitosis maintains the chromosome number in each daughter. Six before copying leads to six in each completed daughter, not six split between them.

Mitosis pathway · 17.2

Extended only (Supplement); Biology 0610, 2026–2028. Use the stated specimen features and evidence. Diagrams are schematic. Written practice is self-checked

Before you begin

  • Recall chromosomes, genes, chromosome sets, selective gene expression and the distinction between a nucleus and a whole cell.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

A six-chromosome parent completes normal mitosis. How many chromosomes are in each daughter?

What you will learn

  • Trace a full complement into each daughter
  • Distinguish maintained number from reduction

Original teaching model. Counts and records are stipulated; drawings are schematic.

Explain why normal mitosis maintains the chromosome numberNormal mitosis maintains the chromosome number in each daughter. Six before copying leads to six in each completed daughter, not six split between them.Supplied chromosome identitiesBefore copying: 6 chromosomesABCDEFExact copying before mitosisABCDEF6 replicated chromosomes; 12 DNA moleculesCopies separateduring mitosisABCDEFABCDEFDaughter 1: 6Daughter 2: 6Every original identity in EACHdaughterBoxes are nuclei; cell division usually follows
Normal mitosis maintains the chromosome number in each daughter. Six before copying leads to six in each completed daughter, not six split between them.
Division, chromosome count and cell-state key
FeatureMeaning
Parent comparisonSix chromosomes before replication
Daughter 1Six chromosomes
Daughter 2Six chromosomes
Both daughters combinedTwelve chromosomes across two cells

Trace a full complement into each daughter

Normal mitosis maintains the chromosome number in each daughter nucleus. The cell first copies its chromosome DNA, then distributes one copy of every chromosome to each product. The copying makes it possible to produce two complete complements rather than splitting a single uncopied list into two incomplete halves. This is the key connection between preparation and the result.

In a stipulated cell with six chromosomes before copying, each daughter cell after normal mitosis and subsequent cell division has six chromosomes. There are twelve chromosomes when the contents of both daughters are added together, but six in each individual daughter. The total across a population and the number per nucleus are different quantities.

Distinguish maintained number from reduction

A division that changes the stated diploid complement to a haploid complement does not fit the chromosome-maintaining mitotic outcome. Meiosis is treated separately in the next syllabus section; this contrast is only a boundary for identifying mitosis, not a replacement for the full meiosis sequence. Gamete formation and fertilisation must not be inserted into the ordinary mitotic copying model.

Count the supplied model at comparable points: the parent before replication and the completed daughter nuclei after separation. During preparation, each replicated chromosome has two attached DNA copies, which can create a counting trap. The later lessons explicitly distinguish chromosome number from DNA-copy number so the maintained-number explanation does not silently change its counting rule.

Pause and explain

Which comparison correctly tests maintained number?

Put the idea to work

Worked example

A parent has six chromosomes. What number is expected in each normal mitotic daughter?

Show the worked solution
  1. Use maintained number per daughter.
  2. Separate that from the sum across both products.

Answer Each daughter has six; both daughters together contain twelve.

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Choose Easy, Normal or Difficult. Save your answers and open worked review after finishing.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

State how copying and separation maintain a six-chromosome complement.

Give me a hint

Give each daughter every represented chromosome.

Compare my reasoning
  1. Copy each chromosome before mitosis.
  2. Separate the copies into two full complements.

Each chromosome is copied before mitosis, then one copy of each is distributed to each daughter nucleus, giving six in each.

Look for these in your work

  • Include copying before division
  • Explain complete distribution
2 · Independent

Two completed daughters each contain eight chromosomes. State the per-cell number and their combined total.

Give me a hint

Do not confuse one cell with both.

Compare my reasoning
  1. Read eight in each cell.
  2. Add eight plus eight.

The per-cell number is eight; the combined total across the two cells is sixteen.

Look for these in your work

  • State the per-cell value
  • Label the combined total
3 · Transfer

A record stipulates that a diploid six-chromosome parent gives haploid three-chromosome products. Does it describe normal mitosis?

Give me a hint

Compare the number and chromosome sets.

Compare my reasoning
  1. Identify the reduction from six to three.
  2. Compare with the maintained-number definition.

No. The stated reduction from diploid to haploid is inconsistent with normal chromosome-maintaining mitosis; full meiosis teaching remains a separate section.

Look for these in your work

  • Identify the reduction
  • Keep the wider section boundary

Common mistakes

  • Use per-cell counts when explaining maintained chromosome number.
  • Mitosis is not the diploid-to-haploid reduction division.
Recall without your notes

What can you explain now?

Which comparison correctly tests maintained number?

Compare with the explanation

Parent before replication versus each completed daughter nucleus

Use comparable complete complements.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Without your notes, trace a full complement into each daughter and distinguish maintained number from reduction. Distinguish nuclear division, chromosome copies and completed daughter cells before opening the solutions.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Biology

Course scope and assessment

780 sequenced lessons provide 2340 guided, independent and application problems in characteristics, classification, cells, organisation, specimen size, membrane transport, biological molecules, enzymes, plant and human nutrition, plant transport, circulatory systems, the heart, blood vessels, blood, disease transmission, body defences, immunity, gas exchange in humans, respiration energy uses and investigations, aerobic respiration, anaerobic respiration and recovery, excretion in humans, coordination and response, sense organs, hormones, homeostasis, tropic responses, drugs, asexual reproduction, sexual reproduction, sexual reproduction in plants, sexual reproduction in humans, sex hormones in humans, sexually transmitted infections, chromosomes, genes and proteins, mitosis, meiosis, monohybrid inheritance, variation, adaptive features, selection, energy flow, food chains and webs, nutrient cycles, population, community, ecosystem, population-growth phases, food supply, habitat destruction, pollution, conservation, biotechnology and genetic modification. 61 of 61 syllabus sections have linked teaching and staged practice. The earlier inheritance overview remains introductory, and the monohybrid pathway develops the relevant Core and Supplement requirements. This is not full programme completion or guaranteed exam readiness. Written practice is self-checked.

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