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IGCSE · Cambridge (CIE) · 0610

Use a bounded X-linked recessive model for red-green colour blindness

Use the required example without claiming male-only expression or a universal colour-vision model.

Monohybrid inheritance pathway · 17.4

Extended only (Supplement); Biology 0610, 2026–2028. Use the stated specimen features and evidence. Diagrams are schematic. Written practice is self-checked

Before you begin

  • Recall chromosomes, genes and alleles, meiosis, haploid gametes and fertilisation restoring two chromosome sets.

Work on paper. Try each question before revealing help, and explain why your method works.

Quick readiness check

Which is the required sex-linkage example here?

What you will learn

  • Classify the supplied red-green model genotypes
  • Distinguish the inheritance example from all colour-vision differences

Original teaching model. Pedigrees and records are fictional; allele and probability assumptions are stated.

Use a bounded X-linked recessive model for red-green colour blindnessUse the required example without claiming male-only expression or a universal colour-vision model.XNXNNo model trait; no n contributionXNXnNo model trait; heterozygous ncarrierXnXnModel trait expressed in an XXgenotypeXNY and XnYNo trait and trait respectively; nocounterpart allele on Y
Use the required example without claiming male-only expression or a universal colour-vision model.
Allele, phenotype and evidence key
FeatureMeaning
XNXNNo model trait; no n contribution
XNXnNo model trait; heterozygous n carrier
XnXnModel trait expressed in an XX genotype
XNY and XnYNo trait and trait respectively; no counterpart allele on Y

Classify the supplied red-green model genotypes

Red-green colour blindness is the required example of sex linkage. Red-green colour-vision differences can make some colour distinctions difficult; this is not the same as seeing every scene only in black and white. The sequence uses a simplified X-linked recessive model to practise inheritance, not a test of a learner’s vision or a complete account of every biological variant.

The key uses XN for the normal-vision model allele and Xn for the recessive red-green-associated model allele. In the usual XX/XY model, XNXN and XNXn do not express the specified feature; XNXn carries n. XnXn expresses it. XNY does not express it and XnY does. These labels follow one supplied locus and are not complete genome records.

Distinguish the inheritance example from all colour-vision differences

The one-copy XnY case has no N counterpart at the locus on Y, so the recessive feature can be expressed with one n contribution. An XX individual requires the two n copies under the classroom rule. This supports the explanation that the X-linked recessive example is more common in males, but does not mean females cannot express it. XnXn is the supplied expressing female genotype.

Other kinds of colour-vision difference can have different causes and inheritance patterns. Even red-green biology involves more detail than this one-locus symbol model. Keep conclusions limited to the explicitly supplied genotypes and normal teaching assumptions. A phenotype, a colour image on screen or a model pedigree is not a personal diagnosis; no population frequency or individual clinical outcome is being measured here.

Pause and explain

Which supplied female genotype expresses the recessive feature?

Put the idea to work

Worked example

Classify five genotypes under the stated usual XX/XY red-green colour-vision model.

Show the worked solution
  1. Read the recessive rule: XNXN and XNXn do not express the feature; XnXn does. The XNXn genotype is an unaffected carrier.
  2. For XY individuals, XNY has N and is unaffected; XnY lacks an N counterpart and expresses the feature. This bounded model does not describe every colour-vision difference.

Answer Model classification: XNXN unaffected; XNXn unaffected carrier; XnXn expresses the feature; XNY unaffected; XnY expresses the feature.

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From guided practice to a new situation

Write your answer and reasoning first. Use a hint only if you are stuck. The model solution is for self-checking; your written work is not automatically marked.

1 · Guided

Classify XNXN, XNXn and XnXn by expression and carrier status under the stated model.

Give me a hint

Apply the N-dominant expression rule to the two X copies.

Compare my reasoning
  1. Identify N in the first two records.
  2. Distinguish the n-carrying heterozygote.
  3. Identify two n copies in the third.

XNXN does not express the feature and does not carry n; XNXn does not express it and is an n carrier; XnXn expresses it.

Look for these in your work

  • Correct expression categories
  • Correct carrier distinction
2 · Independent

Compare XNY and XnY, including why the Y does not make XnY an unaffected carrier in this model.

Give me a hint

The Y has no corresponding N allele at this locus.

Compare my reasoning
  1. Identify N in XNY and n in XnY.
  2. Apply the one-copy expression rule.

XNY does not express the specified feature. XnY expresses it because it has n and no N counterpart on Y; it is not the unaffected heterozygous-carrier case.

Look for these in your work

  • Correct XY expression categories
  • Correct absence of N counterpart explanation
3 · Transfer

Correct the claim that an X-linked recessive example must affect males only and every kind of colour-vision difference follows the same rule.

Give me a hint

Use the supplied female expressing genotype and the model’s scope.

Compare my reasoning
  1. Identify XnXn as an expressing female genotype.
  2. Separate the red-green example from other causes and types.

Females can express the feature as XnXn in this model. It can be more common in males without being male-only, and other colour-vision differences need not follow this simplified red-green inheritance rule.

Look for these in your work

  • Rejects male-only claim using XnXn
  • Keeps the model specific to the supplied example

Common mistakes

  • Saying all colour-vision difference follows this one model
  • Claiming females can never show the X-linked recessive feature
  • Giving Y an N counterpart that the model does not contain
Recall without your notes

What can you explain now?

Which supplied female genotype expresses the recessive feature?

Compare with the explanation

XnXn

Both X-locus copies are n under the model rule.

After trying it yourself, choose your next review. This is your self-assessment.

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Make it stick

Without your notes, classify the supplied red-green model genotypes and distinguish the inheritance example from all colour-vision differences. Use the supplied allele key and state what the evidence can establish.

If you needed the solution, close it and solve the problem again from a blank page. A correct answer is stronger when you can explain the reason for each step.

Keep learning Biology

Course scope and assessment

780 sequenced lessons provide 2340 guided, independent and application problems in characteristics, classification, cells, organisation, specimen size, membrane transport, biological molecules, enzymes, plant and human nutrition, plant transport, circulatory systems, the heart, blood vessels, blood, disease transmission, body defences, immunity, gas exchange in humans, respiration energy uses and investigations, aerobic respiration, anaerobic respiration and recovery, excretion in humans, coordination and response, sense organs, hormones, homeostasis, tropic responses, drugs, asexual reproduction, sexual reproduction, sexual reproduction in plants, sexual reproduction in humans, sex hormones in humans, sexually transmitted infections, chromosomes, genes and proteins, mitosis, meiosis, monohybrid inheritance, variation, adaptive features, selection, energy flow, food chains and webs, nutrient cycles, population, community, ecosystem, population-growth phases, food supply, habitat destruction, pollution, conservation, biotechnology and genetic modification. 61 of 61 syllabus sections have linked teaching and staged practice. The earlier inheritance overview remains introductory, and the monohybrid pathway develops the relevant Core and Supplement requirements. This is not full programme completion or guaranteed exam readiness. Written practice is self-checked.

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